Advanced

QT dispersion failed to estimate the global dispersion of ventricular repolarization measured using monophasic action potential mapping technique in swine and patients

Liang, YC; Kongstad Rasmussen, Ole LU ; Luo, Jijian LU ; Liao, Qiuming LU ; Holm, M; Olsson, Bertil LU and Yuan, Shiwen LU (2005) In Journal of Electrocardiology 38(1). p.19-27
Abstract
The aim of this study was to evaluate whether the QT dispersion measured from 12-lead electrocardiogram (ECG) can estimate the global dispersion of ventricular repolarization (DVR) measured using a monophasic action potential (MAP) mapping technique. Monophasic action potentials were recorded from 75 +/- 12 left ventricular sites in 10 pigs and from 48 +/- 16 left or right ventricular sites in 15 patients using the CARTO mapping system. The maximum DVRs in both end-of-repolarization and MAP duration among all the mapped sites were calculated and termed as global DVR for each measurement. QT intervals, QT(peak) and QT(end), were measured from the 12-lead ECG, and QT dispersions; namely the differences between the maximum and the minimum of... (More)
The aim of this study was to evaluate whether the QT dispersion measured from 12-lead electrocardiogram (ECG) can estimate the global dispersion of ventricular repolarization (DVR) measured using a monophasic action potential (MAP) mapping technique. Monophasic action potentials were recorded from 75 +/- 12 left ventricular sites in 10 pigs and from 48 +/- 16 left or right ventricular sites in 15 patients using the CARTO mapping system. The maximum DVRs in both end-of-repolarization and MAP duration among all the mapped sites were calculated and termed as global DVR for each measurement. QT intervals, QT(peak) and QT(end), were measured from the 12-lead ECG, and QT dispersions; namely the differences between the maximum and the minimum of the QTpeak and QT(end) were calculated. We found that QT dispersions were significantly smaller than (P < .05) and poorly correlated with the global DVRs both in pigs and patients. Bland-Altman agreement analysis demonstrated a marked variation of the differences and an obvious lack of agreement between the results obtained using the ECG and the MAP methods. In our patients, the global DVR increased markedly during ventricular tachycardia as compared with that during sinus rhythm (P < .05), whereas there was no significant difference in QT dispersion between these 2 subgroups. In conclusion, QT dispersion on the surface ECG could not estimate the global DVR measured using the MAP mapping technique. These findings are not consistent with some previously reported observations, suggesting the need for reappraisal of the electrophysiological implications of QT dispersion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dispersion, global, repolarization, QT dispersion, monophasic action potential
in
Journal of Electrocardiology
volume
38
issue
1
pages
19 - 27
publisher
Elsevier
external identifiers
  • wos:000226958500004
  • pmid:15660343
  • scopus:12344336235
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2004.09.012
language
English
LU publication?
yes
id
59cc443d-4dd8-4687-9758-b1f2ae710ace (old id 254357)
date added to LUP
2007-08-23 08:50:28
date last changed
2017-01-01 04:25:18
@article{59cc443d-4dd8-4687-9758-b1f2ae710ace,
  abstract     = {The aim of this study was to evaluate whether the QT dispersion measured from 12-lead electrocardiogram (ECG) can estimate the global dispersion of ventricular repolarization (DVR) measured using a monophasic action potential (MAP) mapping technique. Monophasic action potentials were recorded from 75 +/- 12 left ventricular sites in 10 pigs and from 48 +/- 16 left or right ventricular sites in 15 patients using the CARTO mapping system. The maximum DVRs in both end-of-repolarization and MAP duration among all the mapped sites were calculated and termed as global DVR for each measurement. QT intervals, QT(peak) and QT(end), were measured from the 12-lead ECG, and QT dispersions; namely the differences between the maximum and the minimum of the QTpeak and QT(end) were calculated. We found that QT dispersions were significantly smaller than (P &lt; .05) and poorly correlated with the global DVRs both in pigs and patients. Bland-Altman agreement analysis demonstrated a marked variation of the differences and an obvious lack of agreement between the results obtained using the ECG and the MAP methods. In our patients, the global DVR increased markedly during ventricular tachycardia as compared with that during sinus rhythm (P &lt; .05), whereas there was no significant difference in QT dispersion between these 2 subgroups. In conclusion, QT dispersion on the surface ECG could not estimate the global DVR measured using the MAP mapping technique. These findings are not consistent with some previously reported observations, suggesting the need for reappraisal of the electrophysiological implications of QT dispersion.},
  author       = {Liang, YC and Kongstad Rasmussen, Ole and Luo, Jijian and Liao, Qiuming and Holm, M and Olsson, Bertil and Yuan, Shiwen},
  issn         = {1532-8430},
  keyword      = {dispersion,global,repolarization,QT dispersion,monophasic action potential},
  language     = {eng},
  number       = {1},
  pages        = {19--27},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {QT dispersion failed to estimate the global dispersion of ventricular repolarization measured using monophasic action potential mapping technique in swine and patients},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2004.09.012},
  volume       = {38},
  year         = {2005},
}