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Activation recovery time measurements in evaluation of global sequence and dispersion of ventricular repolarization

Xia, Yunlong LU ; Kongstad Rasmussen, Ole LU ; Hertervig, Eva LU ; Li, Z; Holm, M; Olsson, Bertil LU and Yuan, Shiwen LU (2005) In Journal of Electrocardiology 38(1). p.28-35
Abstract
Introduction: Activation recovery time (ART), defined as the time from the earliest ventricular activation time to the end of T wave on unipolar electrograms, has been used as an index of myocardial repolarization time. However, it is unknown whether the ART can be used to estimate the global sequence and dispersion of ventricular repolarization as determined by the monophasic action potential (MAP) mapping technique. Methods and Results: Endocardial MAPs and unipolar electrograms were simultaneously recorded using the CARTO system from 34 +/- 12 left (n = 6) or right (n = 9) ventricular sites in 12 patients. End-of-repolarization (EOR) times from the MAPs and ARTs from the unipolar electrograms were calculated, based on which 15 sets of... (More)
Introduction: Activation recovery time (ART), defined as the time from the earliest ventricular activation time to the end of T wave on unipolar electrograms, has been used as an index of myocardial repolarization time. However, it is unknown whether the ART can be used to estimate the global sequence and dispersion of ventricular repolarization as determined by the monophasic action potential (MAP) mapping technique. Methods and Results: Endocardial MAPs and unipolar electrograms were simultaneously recorded using the CARTO system from 34 +/- 12 left (n = 6) or right (n = 9) ventricular sites in 12 patients. End-of-repolarization (EOR) times from the MAPs and ARTs from the unipolar electrograms were calculated, based on which 15 sets of 3-dimensional maps of global EOR sequence and ART sequence were reconstructed. The ART sequence was consistent with the EOR sequence in 14 of 15 maps. In the 473 paired measurements obtained, the differences between the ART and the EOR time were 2 +/- 22 milliseconds (NS). A significant positive correlation between the ART and the EOR time was found in all the maps (r = 0.58 +/- 0.22). Agreement analyses showed that the differences between these 2 measurements were almost all within the range of mean difference +/- 2 SD for each individual map and for all the 473 recordings. The global dispersion of ART was 79 +/- 35 milliseconds, as compared with that of EOR time of 78 +/- 35 milliseconds (NS). Conclusion: The ART from unipolar electrograms is a good estimate of EOR time measured from MAPs, suggesting the usefulness of the former in evaluation of global sequence and dispersion of ventricular repolarization. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
repolarization, activation recovery time, monophasic action potential, dispersion
in
Journal of Electrocardiology
volume
38
issue
1
pages
28 - 35
publisher
Elsevier
external identifiers
  • wos:000226958500005
  • pmid:15660344
  • scopus:12344334292
ISSN
1532-8430
DOI
10.1016/j.jelectrocard.2004.09.010
language
English
LU publication?
yes
id
5937b3b2-2516-4682-b05b-93dd8edfbcb5 (old id 254365)
date added to LUP
2007-08-06 13:00:15
date last changed
2017-01-01 05:13:23
@article{5937b3b2-2516-4682-b05b-93dd8edfbcb5,
  abstract     = {Introduction: Activation recovery time (ART), defined as the time from the earliest ventricular activation time to the end of T wave on unipolar electrograms, has been used as an index of myocardial repolarization time. However, it is unknown whether the ART can be used to estimate the global sequence and dispersion of ventricular repolarization as determined by the monophasic action potential (MAP) mapping technique. Methods and Results: Endocardial MAPs and unipolar electrograms were simultaneously recorded using the CARTO system from 34 +/- 12 left (n = 6) or right (n = 9) ventricular sites in 12 patients. End-of-repolarization (EOR) times from the MAPs and ARTs from the unipolar electrograms were calculated, based on which 15 sets of 3-dimensional maps of global EOR sequence and ART sequence were reconstructed. The ART sequence was consistent with the EOR sequence in 14 of 15 maps. In the 473 paired measurements obtained, the differences between the ART and the EOR time were 2 +/- 22 milliseconds (NS). A significant positive correlation between the ART and the EOR time was found in all the maps (r = 0.58 +/- 0.22). Agreement analyses showed that the differences between these 2 measurements were almost all within the range of mean difference +/- 2 SD for each individual map and for all the 473 recordings. The global dispersion of ART was 79 +/- 35 milliseconds, as compared with that of EOR time of 78 +/- 35 milliseconds (NS). Conclusion: The ART from unipolar electrograms is a good estimate of EOR time measured from MAPs, suggesting the usefulness of the former in evaluation of global sequence and dispersion of ventricular repolarization.},
  author       = {Xia, Yunlong and Kongstad Rasmussen, Ole and Hertervig, Eva and Li, Z and Holm, M and Olsson, Bertil and Yuan, Shiwen},
  issn         = {1532-8430},
  keyword      = {repolarization,activation recovery time,monophasic action potential,dispersion},
  language     = {eng},
  number       = {1},
  pages        = {28--35},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {Activation recovery time measurements in evaluation of global sequence and dispersion of ventricular repolarization},
  url          = {http://dx.doi.org/10.1016/j.jelectrocard.2004.09.010},
  volume       = {38},
  year         = {2005},
}