Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci
(2007) In Journal of Clinical Microbiology 45(3). p.948-952- Abstract
- Using data from an ongoing Swedish intervention project, the observed durations of nasopharyngeal carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) (MIC of penicillin G of >= 0.5 mu g/ml) stratified by both pneumococcal serogroup and age of the carrier were compared. The means and 95% confidence intervals (CIs) were estimated by fitting a gamma distribution to the observed duration of carriage for each age and serogroup stratum. The mean observed duration of carriage for all cases was 37 days (95% CI, 35 to 38 days). Children below the age of 5 years carried PNSP for significantly longer periods (43 days; 95% CI, 41 to 45 days) compared with older individuals (25 days; 95% CI, 24 to 27 days). There were also... (More)
- Using data from an ongoing Swedish intervention project, the observed durations of nasopharyngeal carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) (MIC of penicillin G of >= 0.5 mu g/ml) stratified by both pneumococcal serogroup and age of the carrier were compared. The means and 95% confidence intervals (CIs) were estimated by fitting a gamma distribution to the observed duration of carriage for each age and serogroup stratum. The mean observed duration of carriage for all cases was 37 days (95% CI, 35 to 38 days). Children below the age of 5 years carried PNSP for significantly longer periods (43 days; 95% CI, 41 to 45 days) compared with older individuals (25 days; 95% CI, 24 to 27 days). There were also differences within the group of cases below the age of 5 years, as the duration of carriage became significantly shorter for each increasing age step: < 1, 1 to 2, and 3 to 4 years. In addition, patients < 5 years of age carried serogroups 9 and 14 for significantly shorter periods than groups 6 and 23. Serogroup 9 was also carried for significantly shorter periods than group 19. For patients aged 5 years or older, no significant difference in carriage duration for different ages or serogroups could be noted. As young children have the longest duration of PNSP carriage, interventions aiming to reduce the prevalence in this group are of great importance. The results highlight the importance of taking both serogroup and age of the carriers into account when studying the dynamics of pneumococcal transmission in young children. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/669698
- author
- Hogberg, Liselotte ; Geli, Patricia ; Ringberg, Håkan LU ; Melander, Eva ; Lipsitch, Marc and Ekdahl, Karl
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Microbiology
- volume
- 45
- issue
- 3
- pages
- 948 - 952
- publisher
- American Society for Microbiology
- external identifiers
-
- wos:000245071500038
- scopus:33947266177
- ISSN
- 1098-660X
- DOI
- 10.1128/JCM.01913-06
- language
- English
- LU publication?
- yes
- id
- 2544d4eb-dbb5-45a6-ac27-3e67baea86d1 (old id 669698)
- date added to LUP
- 2016-04-01 15:50:22
- date last changed
- 2022-01-28 07:27:49
@article{2544d4eb-dbb5-45a6-ac27-3e67baea86d1, abstract = {{Using data from an ongoing Swedish intervention project, the observed durations of nasopharyngeal carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) (MIC of penicillin G of >= 0.5 mu g/ml) stratified by both pneumococcal serogroup and age of the carrier were compared. The means and 95% confidence intervals (CIs) were estimated by fitting a gamma distribution to the observed duration of carriage for each age and serogroup stratum. The mean observed duration of carriage for all cases was 37 days (95% CI, 35 to 38 days). Children below the age of 5 years carried PNSP for significantly longer periods (43 days; 95% CI, 41 to 45 days) compared with older individuals (25 days; 95% CI, 24 to 27 days). There were also differences within the group of cases below the age of 5 years, as the duration of carriage became significantly shorter for each increasing age step: < 1, 1 to 2, and 3 to 4 years. In addition, patients < 5 years of age carried serogroups 9 and 14 for significantly shorter periods than groups 6 and 23. Serogroup 9 was also carried for significantly shorter periods than group 19. For patients aged 5 years or older, no significant difference in carriage duration for different ages or serogroups could be noted. As young children have the longest duration of PNSP carriage, interventions aiming to reduce the prevalence in this group are of great importance. The results highlight the importance of taking both serogroup and age of the carriers into account when studying the dynamics of pneumococcal transmission in young children.}}, author = {{Hogberg, Liselotte and Geli, Patricia and Ringberg, Håkan and Melander, Eva and Lipsitch, Marc and Ekdahl, Karl}}, issn = {{1098-660X}}, language = {{eng}}, number = {{3}}, pages = {{948--952}}, publisher = {{American Society for Microbiology}}, series = {{Journal of Clinical Microbiology}}, title = {{Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci}}, url = {{http://dx.doi.org/10.1128/JCM.01913-06}}, doi = {{10.1128/JCM.01913-06}}, volume = {{45}}, year = {{2007}}, }