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Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm, T M; Koistinaho, M; Parepalo, M; Vatanen, T; Ooka, Andreas LU ; Karlsson, Stefan LU and Koistinahoa, J (2005) In Neurobiology of Disease 18(1). p.134-142
Abstract
The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. When young transgenic mice were transplanted before the onset of AD-like pathology and the brains analyzed 6.5 months later, the number of engrafted cells was significantly higher than in age-matched wild type mice. Moreover, the number of BM-derived cells associated with... (More)
The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. When young transgenic mice were transplanted before the onset of AD-like pathology and the brains analyzed 6.5 months later, the number of engrafted cells was significantly higher than in age-matched wild type mice. Moreover, the number of BM-derived cells associated with Abeta was significantly higher than in old transgenic mice transplanted after the establishment of AD-like pathology. Local inflammation caused by intrahippocampal lipopolysaccharide injection significantly increased the engraftment of BM-derived cells in old AD mice and decreased the hippocampal Abeta burden. These results suggest that infiltration of BM-derived monocytic cells into the brain contributes to the development of microglial reaction in AD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transplantation, bone marrow, transgenic, Alzheimer's disease, microglia, beta-amyloid, inflammation, recruitment
in
Neurobiology of Disease
volume
18
issue
1
pages
134 - 142
publisher
Elsevier
external identifiers
  • pmid:15649704
  • wos:000226452500013
  • scopus:11844255779
ISSN
0969-9961
DOI
10.1016/j.nbd.2004.09.009
language
English
LU publication?
yes
id
b6e45306-6295-4464-921c-ea363f2d694a (old id 255154)
date added to LUP
2007-08-06 15:59:12
date last changed
2017-08-20 03:46:01
@article{b6e45306-6295-4464-921c-ea363f2d694a,
  abstract     = {The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. When young transgenic mice were transplanted before the onset of AD-like pathology and the brains analyzed 6.5 months later, the number of engrafted cells was significantly higher than in age-matched wild type mice. Moreover, the number of BM-derived cells associated with Abeta was significantly higher than in old transgenic mice transplanted after the establishment of AD-like pathology. Local inflammation caused by intrahippocampal lipopolysaccharide injection significantly increased the engraftment of BM-derived cells in old AD mice and decreased the hippocampal Abeta burden. These results suggest that infiltration of BM-derived monocytic cells into the brain contributes to the development of microglial reaction in AD.},
  author       = {Malm, T M and Koistinaho, M and Parepalo, M and Vatanen, T and Ooka, Andreas and Karlsson, Stefan and Koistinahoa, J},
  issn         = {0969-9961},
  keyword      = {transplantation,bone marrow,transgenic,Alzheimer's disease,microglia,beta-amyloid,inflammation,recruitment},
  language     = {eng},
  number       = {1},
  pages        = {134--142},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice},
  url          = {http://dx.doi.org/10.1016/j.nbd.2004.09.009},
  volume       = {18},
  year         = {2005},
}