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Peptidergic and non-peptidergic innervation and vasomotor responses of human lenticulostriate and posterior cerebral arteries

Jansen-Olesen, I; Gulbenkian, S; Engel, U; Sa, MC and Edvinsson, Lars LU (2004) In Peptides 25(12). p.2105-2114
Abstract
The aim of the present study was to compare in man the innervation pattern and the functional responses to neuronal messengers in medium sized lenticulostriate and branches of the posterior cerebral arteries (PCA). The majority of the nerve fibers found were sympathetic and displayed specific immunoreactivity for tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Only few nerve fibers displayed vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity. In both arteries. the contractions induced by noradrenaline (NA), NPY and 5-hydroxytryptarnine (5-HT) and the relaxant responses induced by acetylcholine (ACh). VIP and pituitary adenylate cyclase activating peptide-27 (PACAP) as... (More)
The aim of the present study was to compare in man the innervation pattern and the functional responses to neuronal messengers in medium sized lenticulostriate and branches of the posterior cerebral arteries (PCA). The majority of the nerve fibers found were sympathetic and displayed specific immunoreactivity for tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Only few nerve fibers displayed vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity. In both arteries. the contractions induced by noradrenaline (NA), NPY and 5-hydroxytryptarnine (5-HT) and the relaxant responses induced by acetylcholine (ACh). VIP and pituitary adenylate cyclase activating peptide-27 (PACAP) as well as CGRP and SP were compared in vitro. In conclusion. there was no major difference in innervation pattern or vasomotor sensitivity (pEC(50) and pIC(50) values) between the two vessels'. However. the general pattern indicates stronger vasomotor responses (E-max and I-max) in the PCA branches as compared to the lenticulostriate arteries which may lend support for the clinical observation of a difference in stroke expression between the two vascular areas. (C) 2004 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CGRP, PACAP, sensory, sympathetic, cerebrovascular, parasympathetic, VIP, NPY, SP
in
Peptides
volume
25
issue
12
pages
2105 - 2114
publisher
Elsevier
external identifiers
  • wos:000226186200008
  • pmid:15572198
  • scopus:9644302661
ISSN
1873-5169
DOI
10.1016/j.peptides.2004.08.002
language
English
LU publication?
yes
id
491d39eb-4140-4c1d-b175-28d2b43c5154 (old id 255984)
date added to LUP
2007-10-23 11:06:06
date last changed
2017-12-10 03:44:38
@article{491d39eb-4140-4c1d-b175-28d2b43c5154,
  abstract     = {The aim of the present study was to compare in man the innervation pattern and the functional responses to neuronal messengers in medium sized lenticulostriate and branches of the posterior cerebral arteries (PCA). The majority of the nerve fibers found were sympathetic and displayed specific immunoreactivity for tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Only few nerve fibers displayed vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity. In both arteries. the contractions induced by noradrenaline (NA), NPY and 5-hydroxytryptarnine (5-HT) and the relaxant responses induced by acetylcholine (ACh). VIP and pituitary adenylate cyclase activating peptide-27 (PACAP) as well as CGRP and SP were compared in vitro. In conclusion. there was no major difference in innervation pattern or vasomotor sensitivity (pEC(50) and pIC(50) values) between the two vessels'. However. the general pattern indicates stronger vasomotor responses (E-max and I-max) in the PCA branches as compared to the lenticulostriate arteries which may lend support for the clinical observation of a difference in stroke expression between the two vascular areas. (C) 2004 Elsevier Inc. All rights reserved.},
  author       = {Jansen-Olesen, I and Gulbenkian, S and Engel, U and Sa, MC and Edvinsson, Lars},
  issn         = {1873-5169},
  keyword      = {CGRP,PACAP,sensory,sympathetic,cerebrovascular,parasympathetic,VIP,NPY,SP},
  language     = {eng},
  number       = {12},
  pages        = {2105--2114},
  publisher    = {Elsevier},
  series       = {Peptides},
  title        = {Peptidergic and non-peptidergic innervation and vasomotor responses of human lenticulostriate and posterior cerebral arteries},
  url          = {http://dx.doi.org/10.1016/j.peptides.2004.08.002},
  volume       = {25},
  year         = {2004},
}