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Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

Borena, Wegene; Strohmaier, Susanne; Lukanova, Annekatrin; Bjorge, Tone; Lindkvist, Bjorn; Hallmans, Goran; Edlinger, Michael; Stocks, Tanja; Nagel, Gabriele and Manjer, Jonas LU , et al. (2012) In International Journal of Cancer 131(1). p.193-200
Abstract
Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an... (More)
Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer. (Less)
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publication status
published
subject
keywords
cohort study, epidemiology, hepatocellular carcinoma, intrahepatic, cholangiocarcinoma, metabolic syndrome
in
International Journal of Cancer
volume
131
issue
1
pages
193 - 200
publisher
John Wiley & Sons
external identifiers
  • wos:000303050100020
  • scopus:84860215803
ISSN
0020-7136
DOI
10.1002/ijc.26338
language
English
LU publication?
yes
id
d178fdeb-dac2-4ff2-808a-4d2d94aef4f3 (old id 2562927)
date added to LUP
2012-06-01 08:43:46
date last changed
2017-10-01 03:20:31
@article{d178fdeb-dac2-4ff2-808a-4d2d94aef4f3,
  abstract     = {Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.},
  author       = {Borena, Wegene and Strohmaier, Susanne and Lukanova, Annekatrin and Bjorge, Tone and Lindkvist, Bjorn and Hallmans, Goran and Edlinger, Michael and Stocks, Tanja and Nagel, Gabriele and Manjer, Jonas and Engeland, Anders and Selmer, Randi and Haggstrom, Christel and Tretli, Steinar and Concin, Hans and Jonsson, Hakan and Stattin, Par and Ulmer, Hanno},
  issn         = {0020-7136},
  keyword      = {cohort study,epidemiology,hepatocellular carcinoma,intrahepatic,cholangiocarcinoma,metabolic syndrome},
  language     = {eng},
  number       = {1},
  pages        = {193--200},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults},
  url          = {http://dx.doi.org/10.1002/ijc.26338},
  volume       = {131},
  year         = {2012},
}