Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease
(2012) In Journal of Gastroenterology and Hepatology 27(5). p.951-956- Abstract
- Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort. Methods: Atotal of 417 Finnish individuals were genotyped for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) influencing liver fat. Plasma apoC3 concentration was measured enzymatically, and liver fat by proton magnetic resonance... (More)
- Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort. Methods: Atotal of 417 Finnish individuals were genotyped for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) influencing liver fat. Plasma apoC3 concentration was measured enzymatically, and liver fat by proton magnetic resonance spectroscopy. Results: APOC3 wild-type homozygotes and variant allele (T-455C or C-482T or both) carriers did not differ with regard to liver fat, apoC3 concentrations, triglyceride-, high density lipoprotein-, fasting plasma glucose, insulin-, alanine aminotransferase-and aspartate aminotransferase-concentrations, nor was there a difference in prevalence of NAFLD. In contrast, carriers of the PNPLA3 GG genotype at rs738409 had a 2.7-fold (median 11.3%) higher liver fat than those with the CC (median 4.2%) genotype. The PNPLA3 rs738409 was also an independent predictor of liver fat, together with age, gender, and body mass index. Conclusion: Genetic variants in PNPLA3 but not APOC3 contribute to the variance in liver fat content due to NAFLD. (Less)
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https://lup.lub.lu.se/record/2563247
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes mellitus type 2, insulin resistance, metabolic syndrome, non-alcoholic fatty liver disease, proton magnetic resonance, spectroscopy
- in
- Journal of Gastroenterology and Hepatology
- volume
- 27
- issue
- 5
- pages
- 951 - 956
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000303039400019
- scopus:84860246794
- pmid:22141340
- ISSN
- 0815-9319
- DOI
- 10.1111/j.1440-1746.2011.07045.x
- language
- English
- LU publication?
- yes
- id
- 0fc69d31-c644-4473-a382-dca36f7328c5 (old id 2563247)
- date added to LUP
- 2016-04-01 14:09:07
- date last changed
- 2024-01-09 23:34:02
@article{0fc69d31-c644-4473-a382-dca36f7328c5, abstract = {{Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort. Methods: Atotal of 417 Finnish individuals were genotyped for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) influencing liver fat. Plasma apoC3 concentration was measured enzymatically, and liver fat by proton magnetic resonance spectroscopy. Results: APOC3 wild-type homozygotes and variant allele (T-455C or C-482T or both) carriers did not differ with regard to liver fat, apoC3 concentrations, triglyceride-, high density lipoprotein-, fasting plasma glucose, insulin-, alanine aminotransferase-and aspartate aminotransferase-concentrations, nor was there a difference in prevalence of NAFLD. In contrast, carriers of the PNPLA3 GG genotype at rs738409 had a 2.7-fold (median 11.3%) higher liver fat than those with the CC (median 4.2%) genotype. The PNPLA3 rs738409 was also an independent predictor of liver fat, together with age, gender, and body mass index. Conclusion: Genetic variants in PNPLA3 but not APOC3 contribute to the variance in liver fat content due to NAFLD.}}, author = {{Hyysalo, Jenni and Stojkovic, Ivana and Kotronen, Anna and Hakkarainen, Antti and Sevastianova, Ksenia and Makkonen, Janne and Lundbom, Nina and Rissanen, Aila and Krauss, Ronald M. and Melander, Olle and Orho-Melander, Marju and Yki-Jarvinen, Hannele}}, issn = {{0815-9319}}, keywords = {{diabetes mellitus type 2; insulin resistance; metabolic syndrome; non-alcoholic fatty liver disease; proton magnetic resonance; spectroscopy}}, language = {{eng}}, number = {{5}}, pages = {{951--956}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Gastroenterology and Hepatology}}, title = {{Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease}}, url = {{http://dx.doi.org/10.1111/j.1440-1746.2011.07045.x}}, doi = {{10.1111/j.1440-1746.2011.07045.x}}, volume = {{27}}, year = {{2012}}, }