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MyelomA Genetics International Consortium

Morgan, Gareth; Johnsen, Hans Erik; Goldschmidt, Hartmut; Palumbo, Antonio; Cavo, Michele; Sonneveld, Pieter; San Miguel, Jesus; Chim, Char Sang; Browne, Paul and Einsele, Hermann, et al. (2012) In Leukemia & Lymphoma 53(5). p.796-800
Abstract
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and... (More)
While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Multiple myeloma, genetics, consortium, etiology
in
Leukemia & Lymphoma
volume
53
issue
5
pages
796 - 800
publisher
Taylor & Francis
external identifiers
  • wos:000303070900010
  • scopus:84859972113
ISSN
1042-8194
DOI
10.3109/10428194.2011.639881
language
English
LU publication?
yes
id
45c531a7-7bd5-4fb3-a370-e1abe8074595 (old id 2563266)
date added to LUP
2012-06-01 08:49:27
date last changed
2017-01-01 06:32:06
@article{45c531a7-7bd5-4fb3-a370-e1abe8074595,
  abstract     = {While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC.},
  author       = {Morgan, Gareth and Johnsen, Hans Erik and Goldschmidt, Hartmut and Palumbo, Antonio and Cavo, Michele and Sonneveld, Pieter and San Miguel, Jesus and Chim, Char Sang and Browne, Paul and Einsele, Hermann and Waage, Anders and Turesson, Ingemar and Spencer, Andrew and Hajek, Roman and Ludwig, Heinz and Hemminki, Kari and Houlston, Richard},
  issn         = {1042-8194},
  keyword      = {Multiple myeloma,genetics,consortium,etiology},
  language     = {eng},
  number       = {5},
  pages        = {796--800},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & Lymphoma},
  title        = {MyelomA Genetics International Consortium},
  url          = {http://dx.doi.org/10.3109/10428194.2011.639881},
  volume       = {53},
  year         = {2012},
}