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An investigation of causal relationships between prediabetes and vascular complications

Mutie, Pascal M. LU ; Pomares-Millan, Hugo LU orcid ; Atabaki-Pasdar, Naeimeh LU orcid ; Jordan, Nina ; Adams, Rachel ; Daly, Nicole L. ; Tajes, Juan Fernandes LU ; Giordano, Giuseppe N. LU and Franks, Paul W. LU (2020) In Nature Communications 11(1).
Abstract

Prediabetes is a state of glycaemic dysregulation below the diagnostic threshold of type 2 diabetes (T2D). Globally, ~352 million people have prediabetes, of which 35–50% develop full-blown diabetes within five years. T2D and its complications are costly to treat, causing considerable morbidity and early mortality. Whether prediabetes is causally related to diabetes complications is unclear. Here we report a causal inference analysis investigating the effects of prediabetes in coronary artery disease, stroke and chronic kidney disease, complemented by a systematic review of relevant observational studies. Although the observational studies suggest that prediabetes is broadly associated with diabetes complications, the causal inference... (More)

Prediabetes is a state of glycaemic dysregulation below the diagnostic threshold of type 2 diabetes (T2D). Globally, ~352 million people have prediabetes, of which 35–50% develop full-blown diabetes within five years. T2D and its complications are costly to treat, causing considerable morbidity and early mortality. Whether prediabetes is causally related to diabetes complications is unclear. Here we report a causal inference analysis investigating the effects of prediabetes in coronary artery disease, stroke and chronic kidney disease, complemented by a systematic review of relevant observational studies. Although the observational studies suggest that prediabetes is broadly associated with diabetes complications, the causal inference analysis revealed that prediabetes is only causally related with coronary artery disease, with no evidence of causal effects on other diabetes complications. In conclusion, prediabetes likely causes coronary artery disease and its prevention is likely to be most effective if initiated prior to the onset of diabetes.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
11
issue
1
article number
4592
publisher
Nature Publishing Group
external identifiers
  • scopus:85090934696
  • pmid:32929089
ISSN
2041-1723
DOI
10.1038/s41467-020-18386-9
language
English
LU publication?
yes
id
256be075-3763-4230-8303-9ad8df5a502f
date added to LUP
2020-09-30 09:01:38
date last changed
2024-06-12 20:55:41
@article{256be075-3763-4230-8303-9ad8df5a502f,
  abstract     = {{<p>Prediabetes is a state of glycaemic dysregulation below the diagnostic threshold of type 2 diabetes (T2D). Globally, ~352 million people have prediabetes, of which 35–50% develop full-blown diabetes within five years. T2D and its complications are costly to treat, causing considerable morbidity and early mortality. Whether prediabetes is causally related to diabetes complications is unclear. Here we report a causal inference analysis investigating the effects of prediabetes in coronary artery disease, stroke and chronic kidney disease, complemented by a systematic review of relevant observational studies. Although the observational studies suggest that prediabetes is broadly associated with diabetes complications, the causal inference analysis revealed that prediabetes is only causally related with coronary artery disease, with no evidence of causal effects on other diabetes complications. In conclusion, prediabetes likely causes coronary artery disease and its prevention is likely to be most effective if initiated prior to the onset of diabetes.</p>}},
  author       = {{Mutie, Pascal M. and Pomares-Millan, Hugo and Atabaki-Pasdar, Naeimeh and Jordan, Nina and Adams, Rachel and Daly, Nicole L. and Tajes, Juan Fernandes and Giordano, Giuseppe N. and Franks, Paul W.}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{An investigation of causal relationships between prediabetes and vascular complications}},
  url          = {{http://dx.doi.org/10.1038/s41467-020-18386-9}},
  doi          = {{10.1038/s41467-020-18386-9}},
  volume       = {{11}},
  year         = {{2020}},
}