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Axillary recurrence rate 5 years after negative sentinel node biopsy for breast cancer

Andersson, Y.; de Boniface, J.; Jonsson, P. -E.; Ingvar, Christian LU ; Liljegren, G.; Bergkvist, L. and Frisell, J. (2012) In British Journal of Surgery 99(2). p.226-231
Abstract
Background: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) as the standard axillary staging procedure in breast cancer. Follow-up studies in SLN-negative women treated without ALND report low rates of axillary recurrence, but most studies have short follow-up, and few are multicentre studies. Methods: Between September 2000 and January 2004, patients who were SLN-negative and did not have ALND were included in a prospective cohort. Kaplan-Meier estimates were used to analyse the rates of axillary recurrence and survival. The risk of axillary recurrence was also compared in centres with high and low experience with the SLN biopsy (SLNB) technique. Results: A total of 2195 patients with 2216 breast... (More)
Background: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) as the standard axillary staging procedure in breast cancer. Follow-up studies in SLN-negative women treated without ALND report low rates of axillary recurrence, but most studies have short follow-up, and few are multicentre studies. Methods: Between September 2000 and January 2004, patients who were SLN-negative and did not have ALND were included in a prospective cohort. Kaplan-Meier estimates were used to analyse the rates of axillary recurrence and survival. The risk of axillary recurrence was also compared in centres with high and low experience with the SLN biopsy (SLNB) technique. Results: A total of 2195 patients with 2216 breast tumours were followed for a median of 65 months. Isolated axillary recurrence was diagnosed in 1.0 per cent of patients. The event-free 5-year survival rate was 88.8 per cent and the overall 5-year survival rate 93.1 per cent. There was no difference in recurrence rates between centres contributing fewer than 150 SLNB procedures to the cohort and centres contributing 150 or more procedures. Conclusion: This study confirmed the low risk of axillary recurrence 5 years after SLNB for breast cancer without ALND. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
99
issue
2
pages
226 - 231
publisher
John Wiley & Sons
external identifiers
  • wos:000303148200012
  • scopus:84855670432
ISSN
1365-2168
DOI
10.1002/bjs.7820
language
English
LU publication?
yes
id
9bc89c20-e04f-442f-85cd-544ed37b2d4d (old id 2570698)
date added to LUP
2012-06-01 08:52:07
date last changed
2017-10-01 03:32:47
@article{9bc89c20-e04f-442f-85cd-544ed37b2d4d,
  abstract     = {Background: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) as the standard axillary staging procedure in breast cancer. Follow-up studies in SLN-negative women treated without ALND report low rates of axillary recurrence, but most studies have short follow-up, and few are multicentre studies. Methods: Between September 2000 and January 2004, patients who were SLN-negative and did not have ALND were included in a prospective cohort. Kaplan-Meier estimates were used to analyse the rates of axillary recurrence and survival. The risk of axillary recurrence was also compared in centres with high and low experience with the SLN biopsy (SLNB) technique. Results: A total of 2195 patients with 2216 breast tumours were followed for a median of 65 months. Isolated axillary recurrence was diagnosed in 1.0 per cent of patients. The event-free 5-year survival rate was 88.8 per cent and the overall 5-year survival rate 93.1 per cent. There was no difference in recurrence rates between centres contributing fewer than 150 SLNB procedures to the cohort and centres contributing 150 or more procedures. Conclusion: This study confirmed the low risk of axillary recurrence 5 years after SLNB for breast cancer without ALND.},
  author       = {Andersson, Y. and de Boniface, J. and Jonsson, P. -E. and Ingvar, Christian and Liljegren, G. and Bergkvist, L. and Frisell, J.},
  issn         = {1365-2168},
  language     = {eng},
  number       = {2},
  pages        = {226--231},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Axillary recurrence rate 5 years after negative sentinel node biopsy for breast cancer},
  url          = {http://dx.doi.org/10.1002/bjs.7820},
  volume       = {99},
  year         = {2012},
}