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Effect of maternal age on uterine flow impedance

Pirhonen, J; Bergersen, TK; Abdlenoor, M; Dubiel, M and Gudmundsson, Saemundur LU (2005) In Journal of Clinical Ultrasound 33(1). p.14-17
Abstract
Purpose. This study was conducted to determine possible maternal age-related changes in uterine artery impedance in normal late pregnancy. Patients and Methods. In a cross-sectional design study, Doppler velocimetry of the uterine vessels was performed in 884 pregnant women with normal, late, singleton pregnancies. We hypothesized that maternal age is associated with changes in uterine blood flow Doppler parameters. We tested for univariate associations and for an adjusted relationship between these factors using a multivariate model to control for confounders. Results. We found a statistically significant, nonlinear relationship between mean uterine artery impedance (pulsatility index) and maternal age, with an increase of the pulsatility... (More)
Purpose. This study was conducted to determine possible maternal age-related changes in uterine artery impedance in normal late pregnancy. Patients and Methods. In a cross-sectional design study, Doppler velocimetry of the uterine vessels was performed in 884 pregnant women with normal, late, singleton pregnancies. We hypothesized that maternal age is associated with changes in uterine blood flow Doppler parameters. We tested for univariate associations and for an adjusted relationship between these factors using a multivariate model to control for confounders. Results. We found a statistically significant, nonlinear relationship between mean uterine artery impedance (pulsatility index) and maternal age, with an increase of the pulsatility index in women above the age of 35. This association continued to be significant even when adjusted for gestational age and parity as confounders. Conclusions. In normal pregnancy, an increase in uterine artery impedance was noted in women above the age of 35. This finding may be related to the physiologic process of aging and may partly explain why pregnancies in older women are associated with diverse complications more often than those in younger women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
normal pregnancy, uterus, maternal age, blood flow, Doppler ultrasonography, index, pulsatility
in
Journal of Clinical Ultrasound
volume
33
issue
1
pages
14 - 17
publisher
John Wiley & Sons
external identifiers
  • pmid:15690442
  • wos:000226005800004
  • scopus:10944258367
ISSN
0091-2751
DOI
10.1002/jcu.20079
language
English
LU publication?
yes
id
a50cbee6-06a4-4d2a-9f62-6e6541580ea9 (old id 257813)
date added to LUP
2007-08-10 16:40:25
date last changed
2017-10-22 04:29:47
@article{a50cbee6-06a4-4d2a-9f62-6e6541580ea9,
  abstract     = {Purpose. This study was conducted to determine possible maternal age-related changes in uterine artery impedance in normal late pregnancy. Patients and Methods. In a cross-sectional design study, Doppler velocimetry of the uterine vessels was performed in 884 pregnant women with normal, late, singleton pregnancies. We hypothesized that maternal age is associated with changes in uterine blood flow Doppler parameters. We tested for univariate associations and for an adjusted relationship between these factors using a multivariate model to control for confounders. Results. We found a statistically significant, nonlinear relationship between mean uterine artery impedance (pulsatility index) and maternal age, with an increase of the pulsatility index in women above the age of 35. This association continued to be significant even when adjusted for gestational age and parity as confounders. Conclusions. In normal pregnancy, an increase in uterine artery impedance was noted in women above the age of 35. This finding may be related to the physiologic process of aging and may partly explain why pregnancies in older women are associated with diverse complications more often than those in younger women.},
  author       = {Pirhonen, J and Bergersen, TK and Abdlenoor, M and Dubiel, M and Gudmundsson, Saemundur},
  issn         = {0091-2751},
  keyword      = {normal pregnancy,uterus,maternal age,blood flow,Doppler ultrasonography,index,pulsatility},
  language     = {eng},
  number       = {1},
  pages        = {14--17},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Clinical Ultrasound},
  title        = {Effect of maternal age on uterine flow impedance},
  url          = {http://dx.doi.org/10.1002/jcu.20079},
  volume       = {33},
  year         = {2005},
}