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Extrinsic and intrinsic factors relating to intimal thickening in children

Pesonen, Erkki LU (2004) In Acta Pædiatrica 93(Suppl. 446). p.43-47
Abstract
Children already have intimal thickenings occupying over half of the vascular lumen. Intimal thickening is one of the first steps in atherogenesis. Classical risk factors such as hypercholesterolaemia, genetic background and acute noxious factors play a role in its development. Genetic origin of the children from high-risk groups for coronary heart disease seems to be a determinant of the magnitude of thickenings. Extrinsic factors such as infections also seem to play a role. The magnitude of the thickening is related to viral and bacterial infections. Infections may lead to endothelial injury and secondary intimal thickening. The process may advance stepwise with acute exacerbations of endothelial dysfunction and intimal thickening... (More)
Children already have intimal thickenings occupying over half of the vascular lumen. Intimal thickening is one of the first steps in atherogenesis. Classical risk factors such as hypercholesterolaemia, genetic background and acute noxious factors play a role in its development. Genetic origin of the children from high-risk groups for coronary heart disease seems to be a determinant of the magnitude of thickenings. Extrinsic factors such as infections also seem to play a role. The magnitude of the thickening is related to viral and bacterial infections. Infections may lead to endothelial injury and secondary intimal thickening. The process may advance stepwise with acute exacerbations of endothelial dysfunction and intimal thickening followed by incomplete healing. In particular, repeated acute infections might lead to permanent damage. Morphological evidence for early atherogendsis in children is presented. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
genetics, atherogenesis, endothelial injury, infections, hypercholesterolemia
in
Acta Pædiatrica
volume
93
issue
Suppl. 446
pages
43 - 47
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000226102000007
  • pmid:15702669
  • scopus:10844278241
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2004.tb00238.x
language
English
LU publication?
yes
id
d7609df9-2879-4cef-a08e-be3db8e6d747 (old id 258169)
date added to LUP
2007-10-29 15:54:24
date last changed
2017-01-01 07:12:31
@article{d7609df9-2879-4cef-a08e-be3db8e6d747,
  abstract     = {Children already have intimal thickenings occupying over half of the vascular lumen. Intimal thickening is one of the first steps in atherogenesis. Classical risk factors such as hypercholesterolaemia, genetic background and acute noxious factors play a role in its development. Genetic origin of the children from high-risk groups for coronary heart disease seems to be a determinant of the magnitude of thickenings. Extrinsic factors such as infections also seem to play a role. The magnitude of the thickening is related to viral and bacterial infections. Infections may lead to endothelial injury and secondary intimal thickening. The process may advance stepwise with acute exacerbations of endothelial dysfunction and intimal thickening followed by incomplete healing. In particular, repeated acute infections might lead to permanent damage. Morphological evidence for early atherogendsis in children is presented.},
  author       = {Pesonen, Erkki},
  issn         = {1651-2227},
  keyword      = {genetics,atherogenesis,endothelial injury,infections,hypercholesterolemia},
  language     = {eng},
  number       = {Suppl. 446},
  pages        = {43--47},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Extrinsic and intrinsic factors relating to intimal thickening in children},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2004.tb00238.x},
  volume       = {93},
  year         = {2004},
}