Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations
(2004) In Journal of Affective Disorders 82(3). p.443-446- Abstract
- Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated... (More)
- Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/258484
- author
- Reis, Margareta LU ; Aberg-Wistedt, A ; Agren, H ; Akerblad, AC and Bengtsson, F
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sertraline, SSRI, depression
- in
- Journal of Affective Disorders
- volume
- 82
- issue
- 3
- pages
- 443 - 446
- publisher
- Elsevier
- external identifiers
-
- pmid:15555696
- wos:000225850600013
- scopus:8844283451
- ISSN
- 1573-2517
- DOI
- 10.1016/j.jad.2004.02.003
- language
- English
- LU publication?
- yes
- id
- 0195f53d-e423-44c9-9a26-e0fa03ee4b0c (old id 258484)
- date added to LUP
- 2016-04-01 11:41:33
- date last changed
- 2022-01-26 08:50:28
@article{0195f53d-e423-44c9-9a26-e0fa03ee4b0c, abstract = {{Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.}}, author = {{Reis, Margareta and Aberg-Wistedt, A and Agren, H and Akerblad, AC and Bengtsson, F}}, issn = {{1573-2517}}, keywords = {{sertraline; SSRI; depression}}, language = {{eng}}, number = {{3}}, pages = {{443--446}}, publisher = {{Elsevier}}, series = {{Journal of Affective Disorders}}, title = {{Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations}}, url = {{http://dx.doi.org/10.1016/j.jad.2004.02.003}}, doi = {{10.1016/j.jad.2004.02.003}}, volume = {{82}}, year = {{2004}}, }