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Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations

Reis, Margareta LU ; Aberg-Wistedt, A; Agren, H; Akerblad, AC and Bengtsson, F (2004) In Journal of Affective Disorders 82(3). p.443-446
Abstract
Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated... (More)
Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sertraline, SSRI, depression
in
Journal of Affective Disorders
volume
82
issue
3
pages
443 - 446
publisher
Elsevier
external identifiers
  • pmid:15555696
  • wos:000225850600013
  • scopus:8844283451
ISSN
1573-2517
DOI
10.1016/j.jad.2004.02.003
language
English
LU publication?
yes
id
0195f53d-e423-44c9-9a26-e0fa03ee4b0c (old id 258484)
date added to LUP
2007-10-26 15:44:50
date last changed
2017-07-09 03:31:26
@article{0195f53d-e423-44c9-9a26-e0fa03ee4b0c,
  abstract     = {Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood. Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements. Result: 9.4% of the per-protocol population in the trial (n = 96) were in either hidden total (n = 4) or hidden partial (n = 5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.},
  author       = {Reis, Margareta and Aberg-Wistedt, A and Agren, H and Akerblad, AC and Bengtsson, F},
  issn         = {1573-2517},
  keyword      = {sertraline,SSRI,depression},
  language     = {eng},
  number       = {3},
  pages        = {443--446},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations},
  url          = {http://dx.doi.org/10.1016/j.jad.2004.02.003},
  volume       = {82},
  year         = {2004},
}