Advanced

Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST study

Sala, Nuria; Munoz, Xavier; Travier, Noemie; Agudo, Antonio; Duell, Eric J.; Moreno, Victor; Overvad, Kim; Tjonneland, Anne; Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise, et al. (2012) In International Journal of Cancer 130(10). p.2417-2427
Abstract
A genome-wide study performed in a Japanese population identified a strong association between SNP rs2294008 (Met1Thr) in the Prostate Stem Cell Antigen gene (PSCA) and diffuse-type gastric cancer (GC). This association was validated in different Asian populations, and, very recently, a study has been published in Caucasians. In this study, we analyzed the association between PSCA variation and GC risk in Caucasians from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Six tagSNPs covering the PSCA gene region were genotyped in 411 incident gastric adenocarcinoma cases and 1530 matched controls from a nested casecontrol study in the EPIC cohort. Associations were analyzed by unconditional logistic regression,... (More)
A genome-wide study performed in a Japanese population identified a strong association between SNP rs2294008 (Met1Thr) in the Prostate Stem Cell Antigen gene (PSCA) and diffuse-type gastric cancer (GC). This association was validated in different Asian populations, and, very recently, a study has been published in Caucasians. In this study, we analyzed the association between PSCA variation and GC risk in Caucasians from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Six tagSNPs covering the PSCA gene region were genotyped in 411 incident gastric adenocarcinoma cases and 1530 matched controls from a nested casecontrol study in the EPIC cohort. Associations were analyzed by unconditional logistic regression, adjusting for age, sex and country. The T allele of rs2294008 in PSCA was found to be a highly significant risk factor for GC (per allele OR = 1.42, 95% CI: 1.231.66, p-value = 6.5 x 10-6), particularly of the noncardia-type (per allele OR = 1.47, 95% CI: 1.191.81, p-value = 3 x 10-4). At contrast with previous studies, no significant differences were observed between the diffuse (per allele OR = 1.54, 95% CI: 1.201.96, p-value = 5 x 10-4) and the intestinal (per allele OR = 1.52, 95% CI: 1.201.93, p-value = 5 x 10-4) GC histological subtypes. Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008. Haplotype analysis did not provide additional information. These results confirm the association between variation in the promoter region of PSCA and GC risk in Caucasians and also indicate that the rs2294008 variant is a similar risk factor for both the diffuse and intestinal-types of GC. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gastric adenocarcinoma, PSCA, genetic susceptibility, Caucasians
in
International Journal of Cancer
volume
130
issue
10
pages
2417 - 2427
publisher
John Wiley & Sons
external identifiers
  • wos:000301579800021
  • scopus:84856569523
ISSN
0020-7136
DOI
10.1002/ijc.26243
language
English
LU publication?
yes
id
b2ec97c2-1e78-41f7-a4bb-4d2e6cd7e4a1 (old id 2587356)
date added to LUP
2012-06-01 09:35:55
date last changed
2017-11-19 03:07:17
@article{b2ec97c2-1e78-41f7-a4bb-4d2e6cd7e4a1,
  abstract     = {A genome-wide study performed in a Japanese population identified a strong association between SNP rs2294008 (Met1Thr) in the Prostate Stem Cell Antigen gene (PSCA) and diffuse-type gastric cancer (GC). This association was validated in different Asian populations, and, very recently, a study has been published in Caucasians. In this study, we analyzed the association between PSCA variation and GC risk in Caucasians from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Six tagSNPs covering the PSCA gene region were genotyped in 411 incident gastric adenocarcinoma cases and 1530 matched controls from a nested casecontrol study in the EPIC cohort. Associations were analyzed by unconditional logistic regression, adjusting for age, sex and country. The T allele of rs2294008 in PSCA was found to be a highly significant risk factor for GC (per allele OR = 1.42, 95% CI: 1.231.66, p-value = 6.5 x 10-6), particularly of the noncardia-type (per allele OR = 1.47, 95% CI: 1.191.81, p-value = 3 x 10-4). At contrast with previous studies, no significant differences were observed between the diffuse (per allele OR = 1.54, 95% CI: 1.201.96, p-value = 5 x 10-4) and the intestinal (per allele OR = 1.52, 95% CI: 1.201.93, p-value = 5 x 10-4) GC histological subtypes. Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008. Haplotype analysis did not provide additional information. These results confirm the association between variation in the promoter region of PSCA and GC risk in Caucasians and also indicate that the rs2294008 variant is a similar risk factor for both the diffuse and intestinal-types of GC.},
  author       = {Sala, Nuria and Munoz, Xavier and Travier, Noemie and Agudo, Antonio and Duell, Eric J. and Moreno, Victor and Overvad, Kim and Tjonneland, Anne and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Canzian, Federico and Kaaks, Rudolf and Boeing, Heiner and Meidtner, Karina and Trichopoulos, Antonia and Tsiotas, Konstantine and Zylis, Dimosthenis and Vineis, Paolo and Panico, Salvatore and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Lund, Eiliv and Bueno-de-Mesquita, H. Bas and Numans, Mattjis E. and Peeters, Petra H. M. and Ramon Quiros, J. and Sanchez, Maria-Jose and Navarro, Camen and Ardanaz, Eva and Dorronsoro, Miren and Hallmans, Goran and Stenling, Roger and Manjer, Jonas and Allen, Naomi E. and Travis, Ruth C. and Khaw, Kay-Tee and Jenab, Mazda and Offerhaus, G. Johan A. and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {0020-7136},
  keyword      = {gastric adenocarcinoma,PSCA,genetic susceptibility,Caucasians},
  language     = {eng},
  number       = {10},
  pages        = {2417--2427},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST study},
  url          = {http://dx.doi.org/10.1002/ijc.26243},
  volume       = {130},
  year         = {2012},
}