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Association between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study

Pyykkonen, Antti-Jussi; Raikkonen, Katri; Tuomi, Tiinamaija; Eriksson, Johan G.; Groop, Leif LU and Isomaa, Bo (2012) In Annals of Medicine 44(3). p.279-288
Abstract
Introduction. To study whether the frequently reported association between depressive symptoms and the metabolic syndrome (MetS) and its individual components are secondary to the use of antidepressant medication and to established diabetes or cardiovascular diseases (CVD). Patients and methods. A population-based, random sample of 4,967 women and men aged 18-75 years. MetS was defined according to the new, harmonized criteria. Glucose tolerance was assessed by oral glucose tolerance test (OGTT). CVD, depressive symptoms, and use of antidepressant medication were self-reported. Results. The odds for having the MetS increased over 10% for each standard deviation increase in depressive symptoms. Users of antidepressant medication had more... (More)
Introduction. To study whether the frequently reported association between depressive symptoms and the metabolic syndrome (MetS) and its individual components are secondary to the use of antidepressant medication and to established diabetes or cardiovascular diseases (CVD). Patients and methods. A population-based, random sample of 4,967 women and men aged 18-75 years. MetS was defined according to the new, harmonized criteria. Glucose tolerance was assessed by oral glucose tolerance test (OGTT). CVD, depressive symptoms, and use of antidepressant medication were self-reported. Results. The odds for having the MetS increased over 10% for each standard deviation increase in depressive symptoms. Users of antidepressant medication had more than 50% increased odds for having the MetS. Depressive symptoms were also associated with higher glucose response during the OGTT, higher serum triglyceride and lower HDL-cholesterol concentrations, and higher waist circumference, while use of antidepressant medication was associated with higher triglycerides, waist circumference, and systolic blood pressure. The associations of depressive symptoms were not secondary to use of antidepressant medication and were not explained by established diabetes or CVD. Discussion. Depressive symptoms, the MetS, and the individual components of MetS are related. These associations are not driven by use of antidepressant medication, established diabetes, or CVD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antidepressive agents, depression, metabolic syndrome
in
Annals of Medicine
volume
44
issue
3
pages
279 - 288
publisher
Informa Healthcare
external identifiers
  • wos:000302319700009
  • scopus:84859365690
ISSN
1365-2060
DOI
10.3109/07853890.2010.543921
language
English
LU publication?
yes
id
ef2494dd-b2a7-4c89-99e3-360096297c88 (old id 2587447)
date added to LUP
2012-06-01 09:35:39
date last changed
2017-10-22 03:15:18
@article{ef2494dd-b2a7-4c89-99e3-360096297c88,
  abstract     = {Introduction. To study whether the frequently reported association between depressive symptoms and the metabolic syndrome (MetS) and its individual components are secondary to the use of antidepressant medication and to established diabetes or cardiovascular diseases (CVD). Patients and methods. A population-based, random sample of 4,967 women and men aged 18-75 years. MetS was defined according to the new, harmonized criteria. Glucose tolerance was assessed by oral glucose tolerance test (OGTT). CVD, depressive symptoms, and use of antidepressant medication were self-reported. Results. The odds for having the MetS increased over 10% for each standard deviation increase in depressive symptoms. Users of antidepressant medication had more than 50% increased odds for having the MetS. Depressive symptoms were also associated with higher glucose response during the OGTT, higher serum triglyceride and lower HDL-cholesterol concentrations, and higher waist circumference, while use of antidepressant medication was associated with higher triglycerides, waist circumference, and systolic blood pressure. The associations of depressive symptoms were not secondary to use of antidepressant medication and were not explained by established diabetes or CVD. Discussion. Depressive symptoms, the MetS, and the individual components of MetS are related. These associations are not driven by use of antidepressant medication, established diabetes, or CVD.},
  author       = {Pyykkonen, Antti-Jussi and Raikkonen, Katri and Tuomi, Tiinamaija and Eriksson, Johan G. and Groop, Leif and Isomaa, Bo},
  issn         = {1365-2060},
  keyword      = {Antidepressive agents,depression,metabolic syndrome},
  language     = {eng},
  number       = {3},
  pages        = {279--288},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {Association between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study},
  url          = {http://dx.doi.org/10.3109/07853890.2010.543921},
  volume       = {44},
  year         = {2012},
}