Business intelligence strategies enables rapid analysis of quantitative proteomics data
Malmström, Lars LU ; Nordenfelt, Pontus LU
and Malmström, Johan
LU
(2012)
In Journal of Proteome Science and Computational Biology
1(1).
p.1-11
- Abstract
- Integration of high throughput data with online data resources is critical for data analysis and hypothesis generation. Relational databases facilitate the data integration, but larger amounts of data and the growth of the online data resources can slow down the data analysis process. We have developed a proof-of-principle software tool using concepts from the business intelligence field to enable fast, reliable and reproducible quantitative analysis of mass spectrometry data. The software allows the user to apply customizable analysis protocols that aggregates the data and stores it in fast and redundant data structures. The user then interacts with these data structures using web-based viewers to gauge data quality, analyze global... (More)
- Integration of high throughput data with online data resources is critical for data analysis and hypothesis generation. Relational databases facilitate the data integration, but larger amounts of data and the growth of the online data resources can slow down the data analysis process. We have developed a proof-of-principle software tool using concepts from the business intelligence field to enable fast, reliable and reproducible quantitative analysis of mass spectrometry data. The software allows the user to apply customizable analysis protocols that aggregates the data and stores it in fast and redundant data structures. The user then interacts with these data structures using web-based viewers to gauge data quality, analyze global properties of the data set and then explore the underlying raw data, which is stored in a tightly integrated relational database. To demonstrate the software we designed an experiment to describe the differentiation of a leukemic cell line, HL-60, to a neutrophil-like phenotype at the molecular level. The concepts described in this paper demonstrates how the new data model enabled rapid overview of the complete experiment in regard of global statistics, statistical calculations of expression profiles and integration with online resources providing deep insight into the data within a few hours. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/258bcf8a-2f15-42d0-81e4-1936ec8036ee
- author
- Malmström, Lars
LU
; Nordenfelt, Pontus
LU
and Malmström, Johan
LU
- organization
- publishing date
- 2012-11-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Proteome Science and Computational Biology
- volume
- 1
- issue
- 1
- pages
- 1 - 11
- publisher
- Herbert Open Access Journals
- ISSN
- 2050-2273
- DOI
- 10.7243/2050-2273-1-5
- language
- English
- LU publication?
- yes
- id
- 258bcf8a-2f15-42d0-81e4-1936ec8036ee
- date added to LUP
- 2017-03-03 10:07:38
- date last changed
- 2019-07-04 02:21:02
@article{258bcf8a-2f15-42d0-81e4-1936ec8036ee,
abstract = {{Integration of high throughput data with online data resources is critical for data analysis and hypothesis generation. Relational databases facilitate the data integration, but larger amounts of data and the growth of the online data resources can slow down the data analysis process. We have developed a proof-of-principle software tool using concepts from the business intelligence field to enable fast, reliable and reproducible quantitative analysis of mass spectrometry data. The software allows the user to apply customizable analysis protocols that aggregates the data and stores it in fast and redundant data structures. The user then interacts with these data structures using web-based viewers to gauge data quality, analyze global properties of the data set and then explore the underlying raw data, which is stored in a tightly integrated relational database. To demonstrate the software we designed an experiment to describe the differentiation of a leukemic cell line, HL-60, to a neutrophil-like phenotype at the molecular level. The concepts described in this paper demonstrates how the new data model enabled rapid overview of the complete experiment in regard of global statistics, statistical calculations of expression profiles and integration with online resources providing deep insight into the data within a few hours.}},
author = {{Malmström, Lars and Nordenfelt, Pontus and Malmström, Johan}},
issn = {{2050-2273}},
language = {{eng}},
month = {{11}},
number = {{1}},
pages = {{1--11}},
publisher = {{Herbert Open Access Journals}},
series = {{Journal of Proteome Science and Computational Biology}},
title = {{Business intelligence strategies enables rapid analysis of quantitative proteomics data}},
url = {{http://dx.doi.org/10.7243/2050-2273-1-5}},
doi = {{10.7243/2050-2273-1-5}},
volume = {{1}},
year = {{2012}},
}