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Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise

Rosendal, L; Larsson, Britt LU ; Kristiansen, J; Peolsson, M; Sogaard, K; Kjaer, M; Sorensen, J and Gerdle, B (2004) In Pain 112(3). p.324-334
Abstract
Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in the trapezius muscle. Baseline pressure pain threshold (PPT) was lower (143+/-18 (TM) vs. 269+/-17 (CON) kPa) (mean +/- SEM), pain intensity (visual analogue scale, VAS) higher (33+/-5 vs. 2+/-1 mm), muscle 5-HT higher (22.9+/-6.7 vs. 3.8+/-1.3 nmol/l), and glutamate higher (47+/-3 vs. 36+/-4 mumol/l) in TM than in CON (all P<0.05), whereas... (More)
Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in the trapezius muscle. Baseline pressure pain threshold (PPT) was lower (143+/-18 (TM) vs. 269+/-17 (CON) kPa) (mean +/- SEM), pain intensity (visual analogue scale, VAS) higher (33+/-5 vs. 2+/-1 mm), muscle 5-HT higher (22.9+/-6.7 vs. 3.8+/-1.3 nmol/l), and glutamate higher (47+/-3 vs. 36+/-4 mumol/l) in TM than in CON (all P<0.05), whereas muscle blood flow was similar in groups. Furthermore, muscle pyruvate was higher (180+/-15 vs. 135+/-12 mumol/l) and lactate higher (4.4+/-0.3 vs. 3.1+/-0.3 mmol/l) in TM than in CON (P<0.001). In response to exercise, VAS and glutamate increased in both TM and CON (all P<0.05). In TM only, lactate and pyruvate increased significantly (P<0.02), whereas blood flow increased to similar levels in both groups. During the initial 20 min recovery period, blood flow remained increased in TM (P<0.005) whereas it decreased to baseline levels in CON. In conclusion, patients with chronic work-related TM have increased levels of muscle 5-HT and glutamate that were correlated to pain intensity (r=0.55, P<0.001) and PPT (r=-0.47, P<0.001), respectively. In addition, TM was associated with increased anaerobic metabolism, whereas a normal rise in blood flow was seen with exercise. These findings indicate that peripheral nociceptive processes are active in work-related TM. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
muscle pain, glutamate, serotonin, lactate, pyruvate, sensitization
in
Pain
volume
112
issue
3
pages
324 - 334
publisher
Elsevier
external identifiers
  • wos:000225601500013
  • pmid:15561388
  • scopus:9244234464
ISSN
1872-6623
DOI
10.1016/j.pain.2004.09.017
language
English
LU publication?
yes
id
620b6833-49df-4cae-9e10-cb78e8a94d51 (old id 259149)
date added to LUP
2007-10-31 09:42:06
date last changed
2017-12-10 03:42:33
@article{620b6833-49df-4cae-9e10-cb78e8a94d51,
  abstract     = {Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in the trapezius muscle. Baseline pressure pain threshold (PPT) was lower (143+/-18 (TM) vs. 269+/-17 (CON) kPa) (mean +/- SEM), pain intensity (visual analogue scale, VAS) higher (33+/-5 vs. 2+/-1 mm), muscle 5-HT higher (22.9+/-6.7 vs. 3.8+/-1.3 nmol/l), and glutamate higher (47+/-3 vs. 36+/-4 mumol/l) in TM than in CON (all P&lt;0.05), whereas muscle blood flow was similar in groups. Furthermore, muscle pyruvate was higher (180+/-15 vs. 135+/-12 mumol/l) and lactate higher (4.4+/-0.3 vs. 3.1+/-0.3 mmol/l) in TM than in CON (P&lt;0.001). In response to exercise, VAS and glutamate increased in both TM and CON (all P&lt;0.05). In TM only, lactate and pyruvate increased significantly (P&lt;0.02), whereas blood flow increased to similar levels in both groups. During the initial 20 min recovery period, blood flow remained increased in TM (P&lt;0.005) whereas it decreased to baseline levels in CON. In conclusion, patients with chronic work-related TM have increased levels of muscle 5-HT and glutamate that were correlated to pain intensity (r=0.55, P&lt;0.001) and PPT (r=-0.47, P&lt;0.001), respectively. In addition, TM was associated with increased anaerobic metabolism, whereas a normal rise in blood flow was seen with exercise. These findings indicate that peripheral nociceptive processes are active in work-related TM. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.},
  author       = {Rosendal, L and Larsson, Britt and Kristiansen, J and Peolsson, M and Sogaard, K and Kjaer, M and Sorensen, J and Gerdle, B},
  issn         = {1872-6623},
  keyword      = {muscle pain,glutamate,serotonin,lactate,pyruvate,sensitization},
  language     = {eng},
  number       = {3},
  pages        = {324--334},
  publisher    = {Elsevier},
  series       = {Pain},
  title        = {Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise},
  url          = {http://dx.doi.org/10.1016/j.pain.2004.09.017},
  volume       = {112},
  year         = {2004},
}