Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia
(2004) In Ethiopian Medical Journal 42(2). p.79-85- Abstract
- Presently, there is no published information on the antimicrobial susceptibility pattern of H. pylori strains in Ethiopia to guide the choice of drug for therapy. Therefore, it is becoming clinically relevant to test the in vitro susceptibility of H. pylori clinical isolates prior to treating patients. Susceptibility testing was performed on 50 clinical H. pylori isolates obtained from adult dyspeptic patients referred to the gastrointestinal (GI) Clinic of Tikur Anbassa University Hospital. Five antibiotics were evaluated, by using the Episolmeter test (E-test). The antibiogram of 50 H. pylori clinical isolates showed that all strains were sensitive to clarithromycin, erythromycin and tetracycline, while 38/50 (76%) and 3/50 (6%) of the... (More)
- Presently, there is no published information on the antimicrobial susceptibility pattern of H. pylori strains in Ethiopia to guide the choice of drug for therapy. Therefore, it is becoming clinically relevant to test the in vitro susceptibility of H. pylori clinical isolates prior to treating patients. Susceptibility testing was performed on 50 clinical H. pylori isolates obtained from adult dyspeptic patients referred to the gastrointestinal (GI) Clinic of Tikur Anbassa University Hospital. Five antibiotics were evaluated, by using the Episolmeter test (E-test). The antibiogram of 50 H. pylori clinical isolates showed that all strains were sensitive to clarithromycin, erythromycin and tetracycline, while 38/50 (76%) and 3/50 (6%) of the strains were resistant to metronidazole and amoxicillin, respectively. Infection by metronidazole or amoxicillin resistant H. pylori is an important factor leading to treatment failure. Testing of all H. pylori clinical isolates to metronidazole and amoxicillin is recommended. If it is not possible to perform susceptibility tests on each clinical isolate, a program to survey the prevalence of resistance should be implemented in a given area or population. When treatment of H. pylori infection is indicated in dyspeptic patients, the potential availability simplicity of use, safety and low cost of the antimicrobial agents have to be taken into account. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/259695
- author
- Asrat, Daniel LU ; Kassa, E ; Mengistu, Y ; Nilsson, Ingrid LU and Wadström, Torkel LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Ethiopian Medical Journal
- volume
- 42
- issue
- 2
- pages
- 79 - 85
- publisher
- Ethiopian Med Assn.
- external identifiers
-
- wos:000225418000002
- pmid:16895024
- scopus:33750103840
- ISSN
- 0014-1755
- language
- English
- LU publication?
- yes
- id
- afe98b65-257a-4b10-a3b6-0263d6d163b5 (old id 259695)
- date added to LUP
- 2016-04-01 15:59:38
- date last changed
- 2022-01-28 08:33:25
@article{afe98b65-257a-4b10-a3b6-0263d6d163b5, abstract = {{Presently, there is no published information on the antimicrobial susceptibility pattern of H. pylori strains in Ethiopia to guide the choice of drug for therapy. Therefore, it is becoming clinically relevant to test the in vitro susceptibility of H. pylori clinical isolates prior to treating patients. Susceptibility testing was performed on 50 clinical H. pylori isolates obtained from adult dyspeptic patients referred to the gastrointestinal (GI) Clinic of Tikur Anbassa University Hospital. Five antibiotics were evaluated, by using the Episolmeter test (E-test). The antibiogram of 50 H. pylori clinical isolates showed that all strains were sensitive to clarithromycin, erythromycin and tetracycline, while 38/50 (76%) and 3/50 (6%) of the strains were resistant to metronidazole and amoxicillin, respectively. Infection by metronidazole or amoxicillin resistant H. pylori is an important factor leading to treatment failure. Testing of all H. pylori clinical isolates to metronidazole and amoxicillin is recommended. If it is not possible to perform susceptibility tests on each clinical isolate, a program to survey the prevalence of resistance should be implemented in a given area or population. When treatment of H. pylori infection is indicated in dyspeptic patients, the potential availability simplicity of use, safety and low cost of the antimicrobial agents have to be taken into account.}}, author = {{Asrat, Daniel and Kassa, E and Mengistu, Y and Nilsson, Ingrid and Wadström, Torkel}}, issn = {{0014-1755}}, language = {{eng}}, number = {{2}}, pages = {{79--85}}, publisher = {{Ethiopian Med Assn.}}, series = {{Ethiopian Medical Journal}}, title = {{Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia}}, volume = {{42}}, year = {{2004}}, }