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A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases

Maranha, Filipy Gobbo LU ; dos Santos Silva, Graciela Aparecida LU ; Bortoluzzi, Adailton J. ; Nordlander, Ebbe LU ; Peralta, Rosely A. and Neves, Ademir (2019) In Inorganica Chimica Acta
Abstract

Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate... (More)

Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diesterase, Hydrolase, Pentanuclear complex
in
Inorganica Chimica Acta
article number
119280
publisher
Elsevier
external identifiers
  • scopus:85076009360
ISSN
0020-1693
DOI
10.1016/j.ica.2019.119280
language
English
LU publication?
yes
id
25bf69a8-f203-41bd-a60b-b159351dc3fd
date added to LUP
2020-01-02 14:06:30
date last changed
2022-04-18 19:44:00
@article{25bf69a8-f203-41bd-a60b-b159351dc3fd,
  abstract     = {{<p>Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe<sub>2</sub> <sup>III</sup>Zn<sub>3</sub> <sup>II</sup>(μ-OH)<sub>3</sub>] structural unit and the unsymmetrical ligand H<sub>2</sub>L<sup>2</sup>-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [Fe<sup>III</sup>(μ-OH)Zn<sup>II</sup>(L<sup>2</sup>-et)] unit that is connected to a second dinuclear [Fe<sup>III</sup>(μ-OH)Zn<sup>II</sup>(L<sup>2</sup>-et)] unit through a hydroxo bridge while a third Zn<sup>II</sup> ion is coordinated by the pendant 1,2-ethanediamine groups of H<sub>2</sub>L<sup>2</sup>-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear Fe<sup>III</sup>Zn<sup>II</sup> complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.</p>}},
  author       = {{Maranha, Filipy Gobbo and dos Santos Silva, Graciela Aparecida and Bortoluzzi, Adailton J. and Nordlander, Ebbe and Peralta, Rosely A. and Neves, Ademir}},
  issn         = {{0020-1693}},
  keywords     = {{Diesterase; Hydrolase; Pentanuclear complex}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Elsevier}},
  series       = {{Inorganica Chimica Acta}},
  title        = {{A new heteropentanuclear complex containing the [Fe<sub>2</sub>                             <sup>III</sup>Zn<sub>3</sub>                             <sup>II</sup>(μ-OH)<sub>3</sub>] structural motif as a model for purple acid phosphatases}},
  url          = {{http://dx.doi.org/10.1016/j.ica.2019.119280}},
  doi          = {{10.1016/j.ica.2019.119280}},
  year         = {{2019}},
}