A new heteropentanuclear complex containing the [Fe2 IIIZn3 II(μ-OH)3] structural motif as a model for purple acid phosphatases
(2019) In Inorganica Chimica Acta- Abstract
Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate... (More)
Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe2 IIIZn3 II(μ-OH)3] structural unit and the unsymmetrical ligand H2L2-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit that is connected to a second dinuclear [FeIII(μ-OH)ZnII(L2-et)] unit through a hydroxo bridge while a third ZnII ion is coordinated by the pendant 1,2-ethanediamine groups of H2L2-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear FeIIIZnII complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.
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- author
- Maranha, Filipy Gobbo LU ; dos Santos Silva, Graciela Aparecida LU ; Bortoluzzi, Adailton J. ; Nordlander, Ebbe LU ; Peralta, Rosely A. and Neves, Ademir
- organization
- publishing date
- 2019-11-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diesterase, Hydrolase, Pentanuclear complex
- in
- Inorganica Chimica Acta
- article number
- 119280
- publisher
- Elsevier
- external identifiers
-
- scopus:85076009360
- ISSN
- 0020-1693
- DOI
- 10.1016/j.ica.2019.119280
- language
- English
- LU publication?
- yes
- id
- 25bf69a8-f203-41bd-a60b-b159351dc3fd
- date added to LUP
- 2020-01-02 14:06:30
- date last changed
- 2022-04-18 19:44:00
@article{25bf69a8-f203-41bd-a60b-b159351dc3fd, abstract = {{<p>Herein, we describe the synthesis and X-ray structure of a new heteropentanuclear complex (2) containing a [Fe<sub>2</sub> <sup>III</sup>Zn<sub>3</sub> <sup>II</sup>(μ-OH)<sub>3</sub>] structural unit and the unsymmetrical ligand H<sub>2</sub>L<sup>2</sup>-et. The molecular structure of (2) shows that it is formed by a basic dinuclear [Fe<sup>III</sup>(μ-OH)Zn<sup>II</sup>(L<sup>2</sup>-et)] unit that is connected to a second dinuclear [Fe<sup>III</sup>(μ-OH)Zn<sup>II</sup>(L<sup>2</sup>-et)] unit through a hydroxo bridge while a third Zn<sup>II</sup> ion is coordinated by the pendant 1,2-ethanediamine groups of H<sub>2</sub>L<sup>2</sup>-et, resulting in the pentanuclear complex. Kinetic studies on the hydrolysis of the substrate 2,4-BDNPP (bis(2,4-dinitrophenyl)phosphate) reveal that (2) shows diesterase activity. While the kinetic activity is comparable to the corresponding dinuclear Fe<sup>III</sup>Zn<sup>II</sup> complex containing the same ligand, the association with 2,4-BDNPP is significantly decreased.</p>}}, author = {{Maranha, Filipy Gobbo and dos Santos Silva, Graciela Aparecida and Bortoluzzi, Adailton J. and Nordlander, Ebbe and Peralta, Rosely A. and Neves, Ademir}}, issn = {{0020-1693}}, keywords = {{Diesterase; Hydrolase; Pentanuclear complex}}, language = {{eng}}, month = {{11}}, publisher = {{Elsevier}}, series = {{Inorganica Chimica Acta}}, title = {{A new heteropentanuclear complex containing the [Fe<sub>2</sub> <sup>III</sup>Zn<sub>3</sub> <sup>II</sup>(μ-OH)<sub>3</sub>] structural motif as a model for purple acid phosphatases}}, url = {{http://dx.doi.org/10.1016/j.ica.2019.119280}}, doi = {{10.1016/j.ica.2019.119280}}, year = {{2019}}, }