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Outcomes of limited fasciectomy, needle fasciotomy and collagenase injection for Dupuytren’s disease : a systematic review and meta-analysis of individual patient data

van den Berge, Bente A. ; Habibi, Hosniya ; Dijkstra, Pieter U. ; Atroshi, Isam LU ; Davis, Tim R.C. ; Jenmalm, Per ; van Rijssen, Annet ; Selles, Ruud W. ; Scherman, Peter LU and Strömberg, Joakim , et al. (2025) In Journal of Hand Surgery: European Volume 50(7). p.878-890
Abstract

This systematic review and meta-analysis of individual patient data evaluates the outcomes of treatment for Dupuytren's disease using limited fasciectomy (LF), percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH) injection. A total of 1423 studies were identified, of which 15 met the eligibility criteria for meta-analysis. The postoperative total extension deficit was smaller after LF than after PNF or CCH, but the difference was not clinically relevant. Minor complications were more frequent after CCH than after LF and PNF. The risk of major complications did not differ between the treatments. Recurrence occurred earlier after PNF and CCH than after LF during 36 months of follow-up. Patient-reported... (More)

This systematic review and meta-analysis of individual patient data evaluates the outcomes of treatment for Dupuytren's disease using limited fasciectomy (LF), percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH) injection. A total of 1423 studies were identified, of which 15 met the eligibility criteria for meta-analysis. The postoperative total extension deficit was smaller after LF than after PNF or CCH, but the difference was not clinically relevant. Minor complications were more frequent after CCH than after LF and PNF. The risk of major complications did not differ between the treatments. Recurrence occurred earlier after PNF and CCH than after LF during 36 months of follow-up. Patient-reported outcome measures showed substantial heterogeneity, which precluded meta-analysis. Overall, the clinically relevant contracture correction was comparable between LF, PNF and CCH, but CCH had a higher risk of minor complications and LF had the longest time to recurrence. Treatment decisions should consider the trade-off between complications and recurrence risk.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
complications, Contracture correction, Dupuytren contracture, recurrence, treatment
in
Journal of Hand Surgery: European Volume
volume
50
issue
7
pages
13 pages
publisher
SAGE Publications
external identifiers
  • pmid:40391547
  • scopus:105007763691
ISSN
1753-1934
DOI
10.1177/17531934251338349
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2025.
id
25ea1c3b-6027-47a0-94d7-a4513c665e8e
date added to LUP
2025-12-15 13:14:06
date last changed
2025-12-15 13:14:32
@article{25ea1c3b-6027-47a0-94d7-a4513c665e8e,
  abstract     = {{<p>This systematic review and meta-analysis of individual patient data evaluates the outcomes of treatment for Dupuytren's disease using limited fasciectomy (LF), percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH) injection. A total of 1423 studies were identified, of which 15 met the eligibility criteria for meta-analysis. The postoperative total extension deficit was smaller after LF than after PNF or CCH, but the difference was not clinically relevant. Minor complications were more frequent after CCH than after LF and PNF. The risk of major complications did not differ between the treatments. Recurrence occurred earlier after PNF and CCH than after LF during 36 months of follow-up. Patient-reported outcome measures showed substantial heterogeneity, which precluded meta-analysis. Overall, the clinically relevant contracture correction was comparable between LF, PNF and CCH, but CCH had a higher risk of minor complications and LF had the longest time to recurrence. Treatment decisions should consider the trade-off between complications and recurrence risk.</p>}},
  author       = {{van den Berge, Bente A. and Habibi, Hosniya and Dijkstra, Pieter U. and Atroshi, Isam and Davis, Tim R.C. and Jenmalm, Per and van Rijssen, Annet and Selles, Ruud W. and Scherman, Peter and Strömberg, Joakim and Skov, Simon T. and Vögelin, Esther and Werker, Paul M.N. and Broekstra, Dieuwke C.}},
  issn         = {{1753-1934}},
  keywords     = {{complications; Contracture correction; Dupuytren contracture; recurrence; treatment}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{878--890}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of Hand Surgery: European Volume}},
  title        = {{Outcomes of limited fasciectomy, needle fasciotomy and collagenase injection for Dupuytren’s disease : a systematic review and meta-analysis of individual patient data}},
  url          = {{http://dx.doi.org/10.1177/17531934251338349}},
  doi          = {{10.1177/17531934251338349}},
  volume       = {{50}},
  year         = {{2025}},
}