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Reversible Michael additions: Covalent inhibitors and prodrugs.

Johansson, Martin H LU (2012) In Mini-Reviews in Medical Chemistry 12(13). p.1330-1344
Abstract
Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mini-Reviews in Medical Chemistry
volume
12
issue
13
pages
1330 - 1344
publisher
Bentham Science Publishers
external identifiers
  • wos:000309968700002
  • pmid:22625413
  • scopus:84870190055
ISSN
1875-5607
language
English
LU publication?
yes
id
dd06d68a-e559-4b42-b8b7-7e01d75946fc (old id 2608516)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22625413?dopt=Abstract
date added to LUP
2012-06-04 20:51:52
date last changed
2017-11-19 04:19:18
@article{dd06d68a-e559-4b42-b8b7-7e01d75946fc,
  abstract     = {Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.},
  author       = {Johansson, Martin H},
  issn         = {1875-5607},
  language     = {eng},
  number       = {13},
  pages        = {1330--1344},
  publisher    = {Bentham Science Publishers},
  series       = {Mini-Reviews in Medical Chemistry},
  title        = {Reversible Michael additions: Covalent inhibitors and prodrugs.},
  volume       = {12},
  year         = {2012},
}