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Impact of vascular aging on cardiovascular disease: the role of telomere biology.

Nilsson-Ehle, Peter LU (2012) In Journal of Hypertension 30. p.9-12
Abstract
Cardiovascular risk increases with chronological as well as biological aging, and one marker of this might be telomere length. The telomere cap is located at the end of the DNA helix and serves to protect its end. This is an evolutionary adaptation which has resulted in stabilization of the DNA strand within the chromosome. During the life course, telomeres tend to shorten in most cells, with the exception of germ line cells and cells that do not undergo cell division as well as cancer cells. Telomeres are typically shorter in men than in women and continue to shorten over the life-span. In certain conditions this shortening is enhanced, especially in the presence of cardiovascular risk factors. There is evidence to suggest that telomere... (More)
Cardiovascular risk increases with chronological as well as biological aging, and one marker of this might be telomere length. The telomere cap is located at the end of the DNA helix and serves to protect its end. This is an evolutionary adaptation which has resulted in stabilization of the DNA strand within the chromosome. During the life course, telomeres tend to shorten in most cells, with the exception of germ line cells and cells that do not undergo cell division as well as cancer cells. Telomeres are typically shorter in men than in women and continue to shorten over the life-span. In certain conditions this shortening is enhanced, especially in the presence of cardiovascular risk factors. There is evidence to suggest that telomere length could be a potential marker of early vascular aging in individuals with a burden of cardiovascular risk factors that might speed up the aging process. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
30
pages
9 - 12
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000304285500003
  • pmid:22573130
  • scopus:84869489267
ISSN
1473-5598
DOI
10.1097/HJH.0b013e328353e512
language
English
LU publication?
yes
id
711ff3bf-63a6-4398-81e3-df2b3e72d94e (old id 2608951)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22573130?dopt=Abstract
date added to LUP
2012-06-03 18:40:19
date last changed
2017-04-02 04:19:35
@article{711ff3bf-63a6-4398-81e3-df2b3e72d94e,
  abstract     = {Cardiovascular risk increases with chronological as well as biological aging, and one marker of this might be telomere length. The telomere cap is located at the end of the DNA helix and serves to protect its end. This is an evolutionary adaptation which has resulted in stabilization of the DNA strand within the chromosome. During the life course, telomeres tend to shorten in most cells, with the exception of germ line cells and cells that do not undergo cell division as well as cancer cells. Telomeres are typically shorter in men than in women and continue to shorten over the life-span. In certain conditions this shortening is enhanced, especially in the presence of cardiovascular risk factors. There is evidence to suggest that telomere length could be a potential marker of early vascular aging in individuals with a burden of cardiovascular risk factors that might speed up the aging process.},
  author       = {Nilsson-Ehle, Peter},
  issn         = {1473-5598},
  language     = {eng},
  pages        = {9--12},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Impact of vascular aging on cardiovascular disease: the role of telomere biology.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328353e512},
  volume       = {30},
  year         = {2012},
}