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The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis.

Gustafsson, Anna; Ljunggren, Lennart; Bodelsson, Mikael LU and Berkestedt, Ingrid LU (2012) In Biomarker Insights 7. p.39-44
Abstract
It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the level of inflammatory activation, severity and mortality. Samples were collected from 27 sepsis patients at the intensive care unit (ICU), Lund, Sweden; 90-day mortalities were registered. The suPAR level was significantly elevated in sepsis patients compared to controls, but not significantly higher in nonsurvivors than survivors. Plasma levels of suPAR did correlate weakly with the SOFA score and myeloperoxidase (MPO) but not with CRP, PCT, IL-6... (More)
It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the level of inflammatory activation, severity and mortality. Samples were collected from 27 sepsis patients at the intensive care unit (ICU), Lund, Sweden; 90-day mortalities were registered. The suPAR level was significantly elevated in sepsis patients compared to controls, but not significantly higher in nonsurvivors than survivors. Plasma levels of suPAR did correlate weakly with the SOFA score and myeloperoxidase (MPO) but not with CRP, PCT, IL-6 or IL-10 in patients with severe sepsis. The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomarker Insights
volume
7
pages
39 - 44
publisher
Libertas Academica
external identifiers
  • pmid:22550400
  • scopus:84860829370
ISSN
1177-2719
DOI
10.4137/BMI.S9460
language
English
LU publication?
yes
id
81367c46-75ff-4a65-a863-aaec01c81b2d (old id 2609235)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22550400?dopt=Abstract
date added to LUP
2012-06-01 12:52:50
date last changed
2017-08-20 04:05:19
@article{81367c46-75ff-4a65-a863-aaec01c81b2d,
  abstract     = {It has been suggested that soluble urokinase plasminogen activator (suPAR) can be used as a marker of disease severity and risk of mortality in sepsis. The aim with the present study was to compare plasma levels of suPAR in patients with severe sepsis to control subjects and correlate it with the level of inflammatory activation, severity and mortality. Samples were collected from 27 sepsis patients at the intensive care unit (ICU), Lund, Sweden; 90-day mortalities were registered. The suPAR level was significantly elevated in sepsis patients compared to controls, but not significantly higher in nonsurvivors than survivors. Plasma levels of suPAR did correlate weakly with the SOFA score and myeloperoxidase (MPO) but not with CRP, PCT, IL-6 or IL-10 in patients with severe sepsis. The weak correlation between suPAR and other inflammatory markers might suggest that suPAR reflects general activation of the immune system rather than exerting inflammatory actions.},
  author       = {Gustafsson, Anna and Ljunggren, Lennart and Bodelsson, Mikael and Berkestedt, Ingrid},
  issn         = {1177-2719},
  language     = {eng},
  pages        = {39--44},
  publisher    = {Libertas Academica},
  series       = {Biomarker Insights},
  title        = {The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis.},
  url          = {http://dx.doi.org/10.4137/BMI.S9460},
  volume       = {7},
  year         = {2012},
}