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Diversification and selection mechanisms for the production of protein repertoires : Lessons from the immune system

Neuberger, Michael S. ; Sale, Julian E. ; Cumbers, Sarah J. ; Jolly, Chris J. ; Bemark, Mats P. LU orcid ; Ehrenstein, Michael R. ; Lanoue, Astrid ; Brüggemann, Marianne ; Batista, Facundo D. and Davies, Sarah L. , et al. (2000) In Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 83(1-3). p.53-62
Abstract

The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation of novel antibody (and heterologous protein) repertoires.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
Antibody, Immunoglobulin, Rerarrangement, Somatic hypermutation, Transgenic mouse
in
Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology
volume
83
issue
1-3
pages
53 - 62
publisher
Humana Press
external identifiers
  • pmid:10826948
  • scopus:0034042445
ISSN
0273-2289
DOI
10.1385/ABAB:83:1-3:53
language
English
LU publication?
no
id
260d0e80-e44c-4570-a8b1-c9702267e2ce
date added to LUP
2023-12-06 17:20:00
date last changed
2024-01-04 15:43:49
@article{260d0e80-e44c-4570-a8b1-c9702267e2ce,
  abstract     = {{<p>The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation of novel antibody (and heterologous protein) repertoires.</p>}},
  author       = {{Neuberger, Michael S. and Sale, Julian E. and Cumbers, Sarah J. and Jolly, Chris J. and Bemark, Mats P. and Ehrenstein, Michael R. and Lanoue, Astrid and Brüggemann, Marianne and Batista, Facundo D. and Davies, Sarah L. and Williams, Gareth T.}},
  issn         = {{0273-2289}},
  keywords     = {{Antibody; Immunoglobulin; Rerarrangement; Somatic hypermutation; Transgenic mouse}},
  language     = {{eng}},
  number       = {{1-3}},
  pages        = {{53--62}},
  publisher    = {{Humana Press}},
  series       = {{Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology}},
  title        = {{Diversification and selection mechanisms for the production of protein repertoires : Lessons from the immune system}},
  url          = {{http://dx.doi.org/10.1385/ABAB:83:1-3:53}},
  doi          = {{10.1385/ABAB:83:1-3:53}},
  volume       = {{83}},
  year         = {{2000}},
}