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Detrusor contraction - Focus on muscarinic receptors

Andersson, Karl-Erik LU (2004) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 38(Suppl 215). p.54-57
Abstract
Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of... (More)
Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sensitivity, calcium, contractile proteins, bladder, signal transduction, acetylcholine
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
38
issue
Suppl 215
pages
54 - 57
publisher
Taylor & Francis
external identifiers
  • wos:000224980100007
  • scopus:9244260506
ISSN
0036-5599
DOI
10.1080/03008880410015192
language
English
LU publication?
yes
id
74ba4ae4-c785-4db1-8d90-42969bb15c93 (old id 261327)
date added to LUP
2007-10-16 13:01:28
date last changed
2017-01-01 06:39:56
@article{74ba4ae4-c785-4db1-8d90-42969bb15c93,
  abstract     = {Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established.},
  author       = {Andersson, Karl-Erik},
  issn         = {0036-5599},
  keyword      = {sensitivity,calcium,contractile proteins,bladder,signal transduction,acetylcholine},
  language     = {eng},
  number       = {Suppl 215},
  pages        = {54--57},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Detrusor contraction - Focus on muscarinic receptors},
  url          = {http://dx.doi.org/10.1080/03008880410015192},
  volume       = {38},
  year         = {2004},
}