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Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?

Ohlsson, Sophie LU ; Wieslander, Jörgen LU and Segelmark, Mårten LU (2004) In Mediators of Inflammation 13(4). p.275-283
Abstract
AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and... (More)
AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammation, autoimmunity, anti-neutrophilic cytoplasmatic autoantibodies, interleukin-10, interleukin-8, vasculitis, interleukin-6
in
Mediators of Inflammation
volume
13
issue
4
pages
275 - 283
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000224975100007
  • pmid:15545059
  • scopus:9644270174
ISSN
0962-9351
DOI
10.1080/09629350400003100
language
English
LU publication?
yes
id
20ddfd87-5b87-4078-8499-e5f9a0b56505 (old id 261697)
date added to LUP
2007-10-29 10:51:32
date last changed
2017-10-29 03:28:18
@article{20ddfd87-5b87-4078-8499-e5f9a0b56505,
  abstract     = {AIMS: The anti-neutrophilic cytoplasmatic autoantibody-associated vasculitides (AASV) are diseases of relapsing-remitting inflammation. Here we explore the cytokine profile in different phases of disease, looking for pathogenic clues of possible prognostic value. Results: Interleukin (IL)-6, IL-8 and IL-10 were significantly elevated in plasma. Patients in the stable phase who subsequently developed adverse events had higher IL-8 values. Patients in the stable phase who relapsed within 3 months had lower IL-10 values and higher IL-6 levels. Conclusions: Patients with AASV have raised circulating cytokine levels compared with healthy controls, even during remission. Raised IL-8 seems associated with poor prognosis. Lower levels of IL-10 and higher levels of IL-6 herald a greater risk of relapse. Patients with systemic vasculitis in clinical remission have persistent disease activity, kept under control by inhibitory cytokines.},
  author       = {Ohlsson, Sophie and Wieslander, Jörgen and Segelmark, Mårten},
  issn         = {0962-9351},
  keyword      = {inflammation,autoimmunity,anti-neutrophilic cytoplasmatic autoantibodies,interleukin-10,interleukin-8,vasculitis,interleukin-6},
  language     = {eng},
  number       = {4},
  pages        = {275--283},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Mediators of Inflammation},
  title        = {Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?},
  url          = {http://dx.doi.org/10.1080/09629350400003100},
  volume       = {13},
  year         = {2004},
}