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Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction

Lopes, SMCDS; Feijen, A; Korving, J; Korchynskyi, O; Larsson, Jonas LU ; Karlsson, Stefan LU ; Ten Dijke, P; Lyons, KM; Goldschmeding, R and Doevendans, P, et al. (2004) In Developmental Dynamics 231(3). p.542-550
Abstract
Connective tissue growth factor (CTGF) is reported to be a target gene of transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) in vitro. Its physiological role in angiogenesis and skeletogenesis during mouse development has been described recently. Here, we have mapped expression of CTGF mRNA during mouse heart development, postnatal adult life, and after experimental myocardial infarction. Furthermore, we investigated the relationship between CTGF and the BMP/TGFbeta signaling pathway in particular during heart development in mutant mice. Postnatally, CTGF expression in the heart became restricted to the atrium. Strikingly, 1 week after myocardial infarction, when myocytes have disappeared from the infarct zone,... (More)
Connective tissue growth factor (CTGF) is reported to be a target gene of transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) in vitro. Its physiological role in angiogenesis and skeletogenesis during mouse development has been described recently. Here, we have mapped expression of CTGF mRNA during mouse heart development, postnatal adult life, and after experimental myocardial infarction. Furthermore, we investigated the relationship between CTGF and the BMP/TGFbeta signaling pathway in particular during heart development in mutant mice. Postnatally, CTGF expression in the heart became restricted to the atrium. Strikingly, 1 week after myocardial infarction, when myocytes have disappeared from the infarct zone, CTGF and TGFbeta expression as well as activated forms of TGFbeta but not BMP, Smad effector proteins are colocalized exclusively in the fibroblasts of the scar tissue, suggesting possible cooperation between CTGF and TGFbeta, during the pathological fibrotic response. (C) 2004 Wiley-Liss, Inc. (Less)
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publication status
published
subject
keywords
myocardial infarction, heart development, mouse, TGF beta, CTGF
in
Developmental Dynamics
volume
231
issue
3
pages
542 - 550
publisher
John Wiley & Sons
external identifiers
  • pmid:15376321
  • wos:000224647500009
  • scopus:6944250333
ISSN
1097-0177
DOI
10.1002/dvdy.20162
language
English
LU publication?
yes
id
ec0b6acb-19e5-4c65-ad67-a6ce491eee97 (old id 262486)
date added to LUP
2007-10-24 20:40:02
date last changed
2017-09-17 05:33:39
@article{ec0b6acb-19e5-4c65-ad67-a6ce491eee97,
  abstract     = {Connective tissue growth factor (CTGF) is reported to be a target gene of transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) in vitro. Its physiological role in angiogenesis and skeletogenesis during mouse development has been described recently. Here, we have mapped expression of CTGF mRNA during mouse heart development, postnatal adult life, and after experimental myocardial infarction. Furthermore, we investigated the relationship between CTGF and the BMP/TGFbeta signaling pathway in particular during heart development in mutant mice. Postnatally, CTGF expression in the heart became restricted to the atrium. Strikingly, 1 week after myocardial infarction, when myocytes have disappeared from the infarct zone, CTGF and TGFbeta expression as well as activated forms of TGFbeta but not BMP, Smad effector proteins are colocalized exclusively in the fibroblasts of the scar tissue, suggesting possible cooperation between CTGF and TGFbeta, during the pathological fibrotic response. (C) 2004 Wiley-Liss, Inc.},
  author       = {Lopes, SMCDS and Feijen, A and Korving, J and Korchynskyi, O and Larsson, Jonas and Karlsson, Stefan and Ten Dijke, P and Lyons, KM and Goldschmeding, R and Doevendans, P and Mummery, CL},
  issn         = {1097-0177},
  keyword      = {myocardial infarction,heart development,mouse,TGF beta,CTGF},
  language     = {eng},
  number       = {3},
  pages        = {542--550},
  publisher    = {John Wiley & Sons},
  series       = {Developmental Dynamics},
  title        = {Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction},
  url          = {http://dx.doi.org/10.1002/dvdy.20162},
  volume       = {231},
  year         = {2004},
}