Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation
(2004) In Breast Cancer Research and Treatment 87(3). p.273-276- Abstract
- We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/262554
- author
- Thomassen, M ; Kruse, TA ; Olsen, KE ; Borg, Åke LU and Gerdes, AM
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hereditary cancer, DCIS, BRCA2, breast cancer, LOH
- in
- Breast Cancer Research and Treatment
- volume
- 87
- issue
- 3
- pages
- 273 - 276
- publisher
- Springer
- external identifiers
-
- wos:000224911000008
- pmid:15528970
- scopus:8644285489
- ISSN
- 1573-7217
- DOI
- 10.1007/s10549-004-9503-3
- language
- English
- LU publication?
- yes
- id
- 525b732b-f046-48f6-8928-ea1d15c60d9b (old id 262554)
- date added to LUP
- 2016-04-01 15:53:54
- date last changed
- 2022-01-28 07:54:59
@article{525b732b-f046-48f6-8928-ea1d15c60d9b, abstract = {{We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.}}, author = {{Thomassen, M and Kruse, TA and Olsen, KE and Borg, Åke and Gerdes, AM}}, issn = {{1573-7217}}, keywords = {{hereditary cancer; DCIS; BRCA2; breast cancer; LOH}}, language = {{eng}}, number = {{3}}, pages = {{273--276}}, publisher = {{Springer}}, series = {{Breast Cancer Research and Treatment}}, title = {{Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation}}, url = {{http://dx.doi.org/10.1007/s10549-004-9503-3}}, doi = {{10.1007/s10549-004-9503-3}}, volume = {{87}}, year = {{2004}}, }