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Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation

Thomassen, M; Kruse, TA; Olsen, KE; Borg, Åke LU and Gerdes, AM (2004) In Breast Cancer Research and Treatment 87(3). p.273-276
Abstract
We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hereditary cancer, DCIS, BRCA2, breast cancer, LOH
in
Breast Cancer Research and Treatment
volume
87
issue
3
pages
273 - 276
publisher
Springer
external identifiers
  • wos:000224911000008
  • pmid:15528970
  • scopus:8644285489
ISSN
1573-7217
DOI
10.1007/s10549-004-9503-3
language
English
LU publication?
yes
id
525b732b-f046-48f6-8928-ea1d15c60d9b (old id 262554)
date added to LUP
2007-11-03 09:35:06
date last changed
2017-01-01 06:49:51
@article{525b732b-f046-48f6-8928-ea1d15c60d9b,
  abstract     = {We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ ( DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.},
  author       = {Thomassen, M and Kruse, TA and Olsen, KE and Borg, Åke and Gerdes, AM},
  issn         = {1573-7217},
  keyword      = {hereditary cancer,DCIS,BRCA2,breast cancer,LOH},
  language     = {eng},
  number       = {3},
  pages        = {273--276},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation},
  url          = {http://dx.doi.org/10.1007/s10549-004-9503-3},
  volume       = {87},
  year         = {2004},
}