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Norovirus epidemiology in community and health care settings and association with patient age, Denmark

Franck, Kristina T ; Fonager, Jannik ; Ersbøll, Annette K and Böttiger, Blenda LU (2014) In Emerging Infectious Diseases 20(7). p.31-1123
Abstract

Norovirus (NoV) is a major cause of gastroenteritis. NoV genotype II.4 (GII.4) is the predominant genotype in health care settings but the reason for this finding is unknown. Stool samples containing isolates with a known NoV genotype from 2,109 patients in Denmark (patients consulting a general practitioner or outpatient clinic, inpatients, and patients from foodborne outbreaks) were used to determine genotype distribution in relation to age and setting. NoV GII.4 was more prevalent among inpatients than among patients in community settings or those who became infected during foodborne outbreaks. In community and health care settings, we found an association between infection with GII.4 and increasing age. Norovirus GII.4 predominated... (More)

Norovirus (NoV) is a major cause of gastroenteritis. NoV genotype II.4 (GII.4) is the predominant genotype in health care settings but the reason for this finding is unknown. Stool samples containing isolates with a known NoV genotype from 2,109 patients in Denmark (patients consulting a general practitioner or outpatient clinic, inpatients, and patients from foodborne outbreaks) were used to determine genotype distribution in relation to age and setting. NoV GII.4 was more prevalent among inpatients than among patients in community settings or those who became infected during foodborne outbreaks. In community and health care settings, we found an association between infection with GII.4 and increasing age. Norovirus GII.4 predominated in patients ≥ 60 years of age and in health care settings. A larger proportion of children than adults were infected with NoV GII.3 or GII.P21. Susceptibility to NoV infection might depend on patient age and infecting NoV genotype. Cohort studies are warranted to test this hypothesis.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Caliciviridae Infections/epidemiology, Child, Child, Preschool, Delivery of Health Care, Denmark/epidemiology, Disease Outbreaks, Feces/virology, Female, Food Microbiology, Genotype, Humans, Male, Middle Aged, Norovirus/genetics, RNA, Viral/genetics, Residence Characteristics, Sequence Analysis, DNA, Young Adult
in
Emerging Infectious Diseases
volume
20
issue
7
pages
9 pages
publisher
Centers for Disease Control and Prevention
external identifiers
  • pmid:24960024
  • scopus:84902817889
ISSN
1080-6040
DOI
10.3201/eid2007.130781
language
English
LU publication?
yes
id
262e2d17-618b-4534-9fb9-33f97e1ba770
date added to LUP
2019-05-02 14:15:40
date last changed
2025-01-09 07:07:13
@article{262e2d17-618b-4534-9fb9-33f97e1ba770,
  abstract     = {{<p>Norovirus (NoV) is a major cause of gastroenteritis. NoV genotype II.4 (GII.4) is the predominant genotype in health care settings but the reason for this finding is unknown. Stool samples containing isolates with a known NoV genotype from 2,109 patients in Denmark (patients consulting a general practitioner or outpatient clinic, inpatients, and patients from foodborne outbreaks) were used to determine genotype distribution in relation to age and setting. NoV GII.4 was more prevalent among inpatients than among patients in community settings or those who became infected during foodborne outbreaks. In community and health care settings, we found an association between infection with GII.4 and increasing age. Norovirus GII.4 predominated in patients ≥ 60 years of age and in health care settings. A larger proportion of children than adults were infected with NoV GII.3 or GII.P21. Susceptibility to NoV infection might depend on patient age and infecting NoV genotype. Cohort studies are warranted to test this hypothesis.</p>}},
  author       = {{Franck, Kristina T and Fonager, Jannik and Ersbøll, Annette K and Böttiger, Blenda}},
  issn         = {{1080-6040}},
  keywords     = {{Adolescent; Adult; Caliciviridae Infections/epidemiology; Child; Child, Preschool; Delivery of Health Care; Denmark/epidemiology; Disease Outbreaks; Feces/virology; Female; Food Microbiology; Genotype; Humans; Male; Middle Aged; Norovirus/genetics; RNA, Viral/genetics; Residence Characteristics; Sequence Analysis, DNA; Young Adult}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{31--1123}},
  publisher    = {{Centers for Disease Control and Prevention}},
  series       = {{Emerging Infectious Diseases}},
  title        = {{Norovirus epidemiology in community and health care settings and association with patient age, Denmark}},
  url          = {{http://dx.doi.org/10.3201/eid2007.130781}},
  doi          = {{10.3201/eid2007.130781}},
  volume       = {{20}},
  year         = {{2014}},
}