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Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema

Gardenfors, F; Nilsson, A; Ungerstedt, U and Nordström, Carl-Henrik LU (2004) In Acta Anaesthesiologica Scandinavica 48(10). p.1316-1321
Abstract
Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously.... (More)
Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI(2) started 1 h before the LPS injection and was constant during the study period. Results: Intracranial pressure increased significantly in animals treated with PGI(2). The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: In LPS-induced brain oedema i.v. infusion of low-dose PGI(2) caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microdialysis, lipopolysaccharide, lactate, intracranial pressure, glycerol, brain oedema, glucose
in
Acta Anaesthesiologica Scandinavica
volume
48
issue
10
pages
1316 - 1321
publisher
Wiley-Blackwell
external identifiers
  • wos:000224727100017
  • pmid:15504195
  • scopus:8544256295
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2004.00522.x
language
English
LU publication?
yes
id
5ce10737-7e30-4785-9c7e-117002fc6b81 (old id 263012)
date added to LUP
2007-08-02 13:25:12
date last changed
2017-01-01 04:46:05
@article{5ce10737-7e30-4785-9c7e-117002fc6b81,
  abstract     = {Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI(2) started 1 h before the LPS injection and was constant during the study period. Results: Intracranial pressure increased significantly in animals treated with PGI(2). The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: In LPS-induced brain oedema i.v. infusion of low-dose PGI(2) caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.},
  author       = {Gardenfors, F and Nilsson, A and Ungerstedt, U and Nordström, Carl-Henrik},
  issn         = {0001-5172},
  keyword      = {microdialysis,lipopolysaccharide,lactate,intracranial pressure,glycerol,brain oedema,glucose},
  language     = {eng},
  number       = {10},
  pages        = {1316--1321},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2004.00522.x},
  volume       = {48},
  year         = {2004},
}