Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema
(2004) In Acta Anaesthesiologica Scandinavica 48(10). p.1316-1321- Abstract
- Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously.... (More)
- Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI(2) started 1 h before the LPS injection and was constant during the study period. Results: Intracranial pressure increased significantly in animals treated with PGI(2). The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: In LPS-induced brain oedema i.v. infusion of low-dose PGI(2) caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/263012
- author
- Gardenfors, F ; Nilsson, A ; Ungerstedt, U and Nordström, Carl-Henrik LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- microdialysis, lipopolysaccharide, lactate, intracranial pressure, glycerol, brain oedema, glucose
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 48
- issue
- 10
- pages
- 1316 - 1321
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000224727100017
- pmid:15504195
- scopus:8544256295
- ISSN
- 0001-5172
- DOI
- 10.1111/j.1399-6576.2004.00522.x
- language
- English
- LU publication?
- yes
- id
- 5ce10737-7e30-4785-9c7e-117002fc6b81 (old id 263012)
- date added to LUP
- 2016-04-01 12:01:40
- date last changed
- 2022-01-26 21:45:11
@article{5ce10737-7e30-4785-9c7e-117002fc6b81,
abstract = {{Background: Prostacyclin (PGI(2)) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI(2) in an experimental model of vasogenic brain oedema. Methods: Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI(2) (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI(2) started 1 h before the LPS injection and was constant during the study period. Results: Intracranial pressure increased significantly in animals treated with PGI(2). The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: In LPS-induced brain oedema i.v. infusion of low-dose PGI(2) caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.}},
author = {{Gardenfors, F and Nilsson, A and Ungerstedt, U and Nordström, Carl-Henrik}},
issn = {{0001-5172}},
keywords = {{microdialysis; lipopolysaccharide; lactate; intracranial pressure; glycerol; brain oedema; glucose}},
language = {{eng}},
number = {{10}},
pages = {{1316--1321}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema}},
url = {{http://dx.doi.org/10.1111/j.1399-6576.2004.00522.x}},
doi = {{10.1111/j.1399-6576.2004.00522.x}},
volume = {{48}},
year = {{2004}},
}