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Modelling the evolution of genomes with integrated external and internal functions

Bengtsson, Bengt Olle LU (2004) In Journal of Theoretical Biology 231(2). p.271-278
Abstract
The genomes that organisms transmit between generations contain information about different kinds of functions. The genome with the "best" mix and number of genes for these functions is the one that natural selection favours. Here I introduce a new way to model simple organisms with genes for external and internal functions, and use it to study the evolution of genome size. The external functions are exemplified by resource use and the internal functions by mutation control (repair). It is shown that even with a suitable proportion of genes for mutation control, the genomes in the organisms do not forever incorporate genes that increase resource use. Instead they evolve towards an optimal genome of limited size. The optimal proportion of... (More)
The genomes that organisms transmit between generations contain information about different kinds of functions. The genome with the "best" mix and number of genes for these functions is the one that natural selection favours. Here I introduce a new way to model simple organisms with genes for external and internal functions, and use it to study the evolution of genome size. The external functions are exemplified by resource use and the internal functions by mutation control (repair). It is shown that even with a suitable proportion of genes for mutation control, the genomes in the organisms do not forever incorporate genes that increase resource use. Instead they evolve towards an optimal genome of limited size. The optimal proportion of genes for mutation control is shown to have an upper limit given by the ease with which transmission accuracy is improved by adding extra genes for this purpose to the genome. The model illustrates how natural selection on genomes integrates systems for the transmission of genetic information with systems relating to the external adaptation of the organism. It also opens Lip for other, more detailed theoretical investigations of genome functions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
systems, gene number, mutation repair, genome evolution, genetic, adaptation
in
Journal of Theoretical Biology
volume
231
issue
2
pages
271 - 278
publisher
Academic Press
external identifiers
  • pmid:15380391
  • wos:000224438000012
  • scopus:4544311326
ISSN
1095-8541
DOI
10.1016/j.jtbi.2004.06.021
language
English
LU publication?
yes
id
0b3e3bd9-d14a-4610-bf67-013d17241a47 (old id 264267)
date added to LUP
2007-10-17 08:12:02
date last changed
2017-01-01 07:07:44
@article{0b3e3bd9-d14a-4610-bf67-013d17241a47,
  abstract     = {The genomes that organisms transmit between generations contain information about different kinds of functions. The genome with the "best" mix and number of genes for these functions is the one that natural selection favours. Here I introduce a new way to model simple organisms with genes for external and internal functions, and use it to study the evolution of genome size. The external functions are exemplified by resource use and the internal functions by mutation control (repair). It is shown that even with a suitable proportion of genes for mutation control, the genomes in the organisms do not forever incorporate genes that increase resource use. Instead they evolve towards an optimal genome of limited size. The optimal proportion of genes for mutation control is shown to have an upper limit given by the ease with which transmission accuracy is improved by adding extra genes for this purpose to the genome. The model illustrates how natural selection on genomes integrates systems for the transmission of genetic information with systems relating to the external adaptation of the organism. It also opens Lip for other, more detailed theoretical investigations of genome functions.},
  author       = {Bengtsson, Bengt Olle},
  issn         = {1095-8541},
  keyword      = {systems,gene number,mutation repair,genome evolution,genetic,adaptation},
  language     = {eng},
  number       = {2},
  pages        = {271--278},
  publisher    = {Academic Press},
  series       = {Journal of Theoretical Biology},
  title        = {Modelling the evolution of genomes with integrated external and internal functions},
  url          = {http://dx.doi.org/10.1016/j.jtbi.2004.06.021},
  volume       = {231},
  year         = {2004},
}