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The impact of active intervention on the spread of penicillin-resistant streptococcus pneumoniae in Swedish day-care centres

Hogberg, L; Normark, BH; Ringberg, H; Stenqvist, K; Fredlund, H; Geli, P; Grabowska, K; Melander, E; Laurell, Martin LU and Ahren, C, et al. (2004) In Scandinavian Journal of Infectious Diseases 36(9). p.629-635
Abstract
Policies for handling cases of penicillin-non-susceptible Streptococcus pneumoniae (PNSP) in day-care groups vary between different counties in Sweden. The aim of this study was to evaluate the epidemiological effect of excluding PNSP-carriers from children's day-care centres (DCC). We followed the incidence in 14 DCC groups with ongoing PNSP-spread, by repeated group screens until no further cases could be identified. All identified carriers were excluded from DCC attendance in study area A (Skane region) while they remained in the group in study area B (Goteborg and Orebro), according to local policies. The intervention effect was evaluated by comparing the number of additional cases after the baseline screen (start of the intervention... (More)
Policies for handling cases of penicillin-non-susceptible Streptococcus pneumoniae (PNSP) in day-care groups vary between different counties in Sweden. The aim of this study was to evaluate the epidemiological effect of excluding PNSP-carriers from children's day-care centres (DCC). We followed the incidence in 14 DCC groups with ongoing PNSP-spread, by repeated group screens until no further cases could be identified. All identified carriers were excluded from DCC attendance in study area A (Skane region) while they remained in the group in study area B (Goteborg and Orebro), according to local policies. The intervention effect was evaluated by comparing the number of additional cases after the baseline screen (start of the intervention period) between the 2 study areas. All PNSP-isolates were characterized by resistance pattern, serotype and pulse-field gel electrophoresis. The relative risk for children in DCCs without active intervention was 6.4 (95% CI: 2.0-20.7). Each prevented case in area A can be estimated to have demanded the exclusion of 2 other children from day care for approximately 4 weeks each. The total cost-benefit outcome of this action has to be seen in the light of the local situation with regard to the population prevalence and the distribution of other risk factors. (Less)
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Scandinavian Journal of Infectious Diseases
volume
36
issue
9
pages
629 - 635
publisher
Informa Healthcare
external identifiers
  • wos:000224263400001
  • scopus:4644346432
ISSN
1651-1980
DOI
10.1080/00365540410022594
language
English
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yes
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5b30f0a5-883b-4b30-a749-ad01e3ac7602 (old id 265546)
date added to LUP
2007-10-26 16:02:35
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2017-11-12 03:50:39
@article{5b30f0a5-883b-4b30-a749-ad01e3ac7602,
  abstract     = {Policies for handling cases of penicillin-non-susceptible Streptococcus pneumoniae (PNSP) in day-care groups vary between different counties in Sweden. The aim of this study was to evaluate the epidemiological effect of excluding PNSP-carriers from children's day-care centres (DCC). We followed the incidence in 14 DCC groups with ongoing PNSP-spread, by repeated group screens until no further cases could be identified. All identified carriers were excluded from DCC attendance in study area A (Skane region) while they remained in the group in study area B (Goteborg and Orebro), according to local policies. The intervention effect was evaluated by comparing the number of additional cases after the baseline screen (start of the intervention period) between the 2 study areas. All PNSP-isolates were characterized by resistance pattern, serotype and pulse-field gel electrophoresis. The relative risk for children in DCCs without active intervention was 6.4 (95% CI: 2.0-20.7). Each prevented case in area A can be estimated to have demanded the exclusion of 2 other children from day care for approximately 4 weeks each. The total cost-benefit outcome of this action has to be seen in the light of the local situation with regard to the population prevalence and the distribution of other risk factors.},
  author       = {Hogberg, L and Normark, BH and Ringberg, H and Stenqvist, K and Fredlund, H and Geli, P and Grabowska, K and Melander, E and Laurell, Martin and Ahren, C and Tornqvist, E and Falt, R and Hoglund, D and Mollerberg, G and Ekdahl, K},
  issn         = {1651-1980},
  language     = {eng},
  number       = {9},
  pages        = {629--635},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {The impact of active intervention on the spread of penicillin-resistant streptococcus pneumoniae in Swedish day-care centres},
  url          = {http://dx.doi.org/10.1080/00365540410022594},
  volume       = {36},
  year         = {2004},
}