Psychiatric disorders among survivors of childhood acute lymphoblastic leukemia in Denmark and Sweden
(2024) In Pediatric Blood and Cancer 71(12).- Abstract
Background: The diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long-term risk of psychiatric disorders among survivors of ALL in a population-based cohort study. Methods: We identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and population comparison subjects (n = 9713) were followed for hospital contacts for psychiatric disorders from 5 years after ALL diagnosis (or corresponding index date) until 2017. Results: By age 30, the absolute risk of psychiatric hospital contacts was 19.9% (95% confidence interval [CI]: 17.9–22.1) for ALL survivors, 18.5% (95% CI: 16.9–20.2)... (More)
Background: The diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long-term risk of psychiatric disorders among survivors of ALL in a population-based cohort study. Methods: We identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and population comparison subjects (n = 9713) were followed for hospital contacts for psychiatric disorders from 5 years after ALL diagnosis (or corresponding index date) until 2017. Results: By age 30, the absolute risk of psychiatric hospital contacts was 19.9% (95% confidence interval [CI]: 17.9–22.1) for ALL survivors, 18.5% (95% CI: 16.9–20.2) for siblings, and 18.3% (95% CI: 17.3–19.2) for population comparison subjects. Overall, survivors were at higher risk of any psychiatric disorders than siblings (hazard ratio [HR] = 1.25; 95% CI: 1.04–1.50), and population comparison subjects (HR = 1.20; 95% CI: 1.06–1.35). The subgroup of survivors (n = 332) who received a hematopoietic stem cell transplantation (HSCT) and/or had a relapse were at highest risk of psychiatric disorders (HR = 2.07; 95% CI: 1.26–3.41 compared to siblings; HR = 1.67; 95% CI: 1.25–2.23 compared to population comparison subjects). Conclusions: The overall absolute risk of psychiatric hospital contacts among ALL survivors was close to that in siblings and population comparison subjects. The modestly increased relative risk was mainly driven by the subgroup of survivors who received HSCT and/or had a relapse. Our findings are reassuring for the large subgroup of ALL survivors without HSCT or relapse, and provide novel insight on both absolute and relative risk of hospital contacts for psychiatric disorders.
(Less)
- author
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute lymphoblastic leukemia, childhood cancer, hospitalization, late effects, mental health, psychiatric disorders, register-based study
- in
- Pediatric Blood and Cancer
- volume
- 71
- issue
- 12
- article number
- e31361
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:39375822
- scopus:85205684789
- ISSN
- 1545-5009
- DOI
- 10.1002/pbc.31361
- language
- English
- LU publication?
- yes
- id
- 265640df-a060-4d70-979d-cdf640067acd
- date added to LUP
- 2024-12-20 09:43:35
- date last changed
- 2025-07-05 02:02:15
@article{265640df-a060-4d70-979d-cdf640067acd,
abstract = {{<p>Background: The diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long-term risk of psychiatric disorders among survivors of ALL in a population-based cohort study. Methods: We identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and population comparison subjects (n = 9713) were followed for hospital contacts for psychiatric disorders from 5 years after ALL diagnosis (or corresponding index date) until 2017. Results: By age 30, the absolute risk of psychiatric hospital contacts was 19.9% (95% confidence interval [CI]: 17.9–22.1) for ALL survivors, 18.5% (95% CI: 16.9–20.2) for siblings, and 18.3% (95% CI: 17.3–19.2) for population comparison subjects. Overall, survivors were at higher risk of any psychiatric disorders than siblings (hazard ratio [HR] = 1.25; 95% CI: 1.04–1.50), and population comparison subjects (HR = 1.20; 95% CI: 1.06–1.35). The subgroup of survivors (n = 332) who received a hematopoietic stem cell transplantation (HSCT) and/or had a relapse were at highest risk of psychiatric disorders (HR = 2.07; 95% CI: 1.26–3.41 compared to siblings; HR = 1.67; 95% CI: 1.25–2.23 compared to population comparison subjects). Conclusions: The overall absolute risk of psychiatric hospital contacts among ALL survivors was close to that in siblings and population comparison subjects. The modestly increased relative risk was mainly driven by the subgroup of survivors who received HSCT and/or had a relapse. Our findings are reassuring for the large subgroup of ALL survivors without HSCT or relapse, and provide novel insight on both absolute and relative risk of hospital contacts for psychiatric disorders.</p>}},
author = {{Sørensen, Gitte V. and Mogensen, Hanna and Holmqvist, Anna S. and Kenborg, Line and Pedersen, Camilla and Nielsen, Thomas T. and Talbäck, Mats and Erdmann, Friederike and Ifversen, Marianne and Feychting, Maria and Schmiegelow, Kjeld and Heyman, Mats M. and Winther, Jeanette F. and Hasle, Henrik and Frederiksen, Line E.}},
issn = {{1545-5009}},
keywords = {{acute lymphoblastic leukemia; childhood cancer; hospitalization; late effects; mental health; psychiatric disorders; register-based study}},
language = {{eng}},
number = {{12}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Pediatric Blood and Cancer}},
title = {{Psychiatric disorders among survivors of childhood acute lymphoblastic leukemia in Denmark and Sweden}},
url = {{http://dx.doi.org/10.1002/pbc.31361}},
doi = {{10.1002/pbc.31361}},
volume = {{71}},
year = {{2024}},
}