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Cdk2 as a master of S phase entry : Fact or fake?

Aleem, Eiman ; Berthet, Cyril and Kaldis, Philipp LU orcid (2004) In Cell Cycle 3(1). p.34-36
Abstract

It has long been believed that Cdk2 and its activator cyclin E play essential roles in the progression of the mitotic cell cycle. However, recent studies using knockout mouse models revealed that neither Cdk2 nor cyclin E are essential in vivo. The purpose of this Perspective is to compare both Cdk2 and cyclin E knockout mice models and to discuss potential mechanisms driving the cell cycle in the absence of Cdk2 or cyclin E. Particular emphasis is placed on possible non-catalytic roles of cyclin E, the expression and activity of the second cyclin binding partner of Cdk2, cyclin A, as well as on the expression and degradation of the Cdk2 inhibitor p27Kip1 in the absence of Cdk2.

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author
; and
publishing date
type
Contribution to journal
publication status
published
keywords
Cdk2, Cdk4, Cyclin A, Cyclin E, p27, S phase
in
Cell Cycle
volume
3
issue
1
pages
34 - 36
publisher
Landes Bioscience
external identifiers
  • scopus:1542357279
  • pmid:14657662
ISSN
1538-4101
DOI
10.4161/cc.3.1.632
language
English
LU publication?
no
id
265c80d7-f55e-434d-a04d-01526d013ff5
date added to LUP
2019-09-18 14:29:10
date last changed
2024-01-01 20:41:03
@article{265c80d7-f55e-434d-a04d-01526d013ff5,
  abstract     = {{<p>It has long been believed that Cdk2 and its activator cyclin E play essential roles in the progression of the mitotic cell cycle. However, recent studies using knockout mouse models revealed that neither Cdk2 nor cyclin E are essential in vivo. The purpose of this Perspective is to compare both Cdk2 and cyclin E knockout mice models and to discuss potential mechanisms driving the cell cycle in the absence of Cdk2 or cyclin E. Particular emphasis is placed on possible non-catalytic roles of cyclin E, the expression and activity of the second cyclin binding partner of Cdk2, cyclin A, as well as on the expression and degradation of the Cdk2 inhibitor p27<sup>Kip1</sup> in the absence of Cdk2.</p>}},
  author       = {{Aleem, Eiman and Berthet, Cyril and Kaldis, Philipp}},
  issn         = {{1538-4101}},
  keywords     = {{Cdk2; Cdk4; Cyclin A; Cyclin E; p27; S phase}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{34--36}},
  publisher    = {{Landes Bioscience}},
  series       = {{Cell Cycle}},
  title        = {{Cdk2 as a master of S phase entry : Fact or fake?}},
  url          = {{http://dx.doi.org/10.4161/cc.3.1.632}},
  doi          = {{10.4161/cc.3.1.632}},
  volume       = {{3}},
  year         = {{2004}},
}