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Epidemiological evidence on reproductive effects of persistent organochlorines in humans

Toft, G; Hagmar, L; Giwercman, Aleksander LU and Bonde, JP (2004) In Reproductive Toxicology 19(1). p.5-26
Abstract
Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day... (More)
Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endocrine disruption, fertility, reproduction, DDE, DDT, organochlorines, PCB, human
in
Reproductive Toxicology
volume
19
issue
1
pages
5 - 26
publisher
Elsevier
external identifiers
  • wos:000224020900003
  • pmid:15336708
  • scopus:4444312867
ISSN
1873-1708
DOI
10.1016/j.reprotox.2004.05.006
language
English
LU publication?
yes
id
b5522ea9-e435-4e54-82b1-140a7e8cc8b6 (old id 266664)
date added to LUP
2007-11-03 09:50:08
date last changed
2017-12-10 04:27:00
@article{b5522ea9-e435-4e54-82b1-140a7e8cc8b6,
  abstract     = {Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved.},
  author       = {Toft, G and Hagmar, L and Giwercman, Aleksander and Bonde, JP},
  issn         = {1873-1708},
  keyword      = {endocrine disruption,fertility,reproduction,DDE,DDT,organochlorines,PCB,human},
  language     = {eng},
  number       = {1},
  pages        = {5--26},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Epidemiological evidence on reproductive effects of persistent organochlorines in humans},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2004.05.006},
  volume       = {19},
  year         = {2004},
}