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Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry

Bastlund, JF; Jennum, P; Mohapel, Paul LU ; Vogel, V and Watson, W P (2004) In Journal of Neuroscience Methods 138(1-2). p.65-72
Abstract
Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform... (More)
Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform ictal and interictal activity following an acute injection of either 40 mg/kg pentylenetetrazole (PTZ) or 13.8 mg/kg kainic acid (KA) was investigated. The occurrence of spontaneous seizures was also monitored 5-8 weeks after administration of KA. The present study demonstrated a sensitive method for monitoring cortical EEG, hippocampal EEG and EMG short and long-term by implantable radiotelemetry in freely moving rats. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pentylenetetrazole, kainate, activity, epileptiform, electromyogram, radiotelemetry, electroencephalogram, cortex, hippocampus
in
Journal of Neuroscience Methods
volume
138
issue
1-2
pages
65 - 72
publisher
Elsevier
external identifiers
  • pmid:15325113
  • wos:000223804600009
  • scopus:7744222156
ISSN
1872-678X
DOI
10.1016/j.jneumeth.2004.03.004
language
English
LU publication?
yes
id
ddc8d8b3-db73-4c68-8c43-3d3c456ed0f6 (old id 267376)
date added to LUP
2007-10-16 16:43:50
date last changed
2017-06-25 03:39:37
@article{ddc8d8b3-db73-4c68-8c43-3d3c456ed0f6,
  abstract     = {Implanted radiotelemetry has been used for the measurement of cortical electroencephalogram (EEG), locomotor activity, body temperature and cardiovascular parameters. This technique allows high quality data acquisition from freely moving animals with no complications of externalised apparatus. This paper focuses on the methodology for short and long-term monitoring of epileptiform activity by simultaneous cortical EEG, hippocampal (HC) EEG and electromyogram (EMG) in rats. The circadian rhythm of temperature (CRT) was monitored after surgery to estimate the need for post surgical recovery of animals. Different placements of EMG electrodes were assessed in order to minimise artefacts and increase sensitivity. The occurrence of epileptiform ictal and interictal activity following an acute injection of either 40 mg/kg pentylenetetrazole (PTZ) or 13.8 mg/kg kainic acid (KA) was investigated. The occurrence of spontaneous seizures was also monitored 5-8 weeks after administration of KA. The present study demonstrated a sensitive method for monitoring cortical EEG, hippocampal EEG and EMG short and long-term by implantable radiotelemetry in freely moving rats.},
  author       = {Bastlund, JF and Jennum, P and Mohapel, Paul and Vogel, V and Watson, W P},
  issn         = {1872-678X},
  keyword      = {pentylenetetrazole,kainate,activity,epileptiform,electromyogram,radiotelemetry,electroencephalogram,cortex,hippocampus},
  language     = {eng},
  number       = {1-2},
  pages        = {65--72},
  publisher    = {Elsevier},
  series       = {Journal of Neuroscience Methods},
  title        = {Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry},
  url          = {http://dx.doi.org/10.1016/j.jneumeth.2004.03.004},
  volume       = {138},
  year         = {2004},
}