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Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer

Hardell, L; van Bavel, B; Lindstrom, G; Carlberg, M; Eriksson, Mikael LU ; Dreifaldt, AC; Wijkstrom, H; Starkhammar, H; Hallquist, A and Kolmert, T (2004) In International Journal of Andrology 27(5). p.282-290
Abstract
An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB) and chlordanes in 58 cases with testicular cancer, 61 age-matched controls and 44 case mothers and 45 control mothers. In that report, significant increase of odds ratio (OR) was found for sum of PCBs, HCB, trans- and cis-nonachlordane in case mothers. These data have... (More)
An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB) and chlordanes in 58 cases with testicular cancer, 61 age-matched controls and 44 case mothers and 45 control mothers. In that report, significant increase of odds ratio (OR) was found for sum of PCBs, HCB, trans- and cis-nonachlordane in case mothers. These data have now been further analysed for 37 congeners of PCBs. No significant differences were found among cases and controls. However, case mothers had significantly increased concentrations of a number of PCB congeners. A priori decided grouping of PCBs yielded for oestrogenic PCBs OR = 2.4, 95% confidence interval (CI) = 0.95-6.0, enzyme-inducing PCBsOR = 2.6, 95% CI = 1.03-6.5 and toxic equivalents (TEQ) yielded OR = 3.3, 95% CI = 1.3-8.4. These data further elucidate the role of foetal exposure to different PCB congeners in the aetiology of testicular cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polychlorinated biphenyls, aetiology, perinatal exposure, testicular, cancer
in
International Journal of Andrology
volume
27
issue
5
pages
282 - 290
publisher
Wiley-Blackwell
external identifiers
  • wos:000223997300005
  • pmid:15379968
  • scopus:5644248141
ISSN
0105-6263
DOI
10.1111/j.1365-2605.2004.00489.x
language
English
LU publication?
yes
id
b4d2dd82-4004-4819-a62c-ff0404b626b9 (old id 267436)
date added to LUP
2007-10-22 14:40:31
date last changed
2017-07-09 04:27:02
@article{b4d2dd82-4004-4819-a62c-ff0404b626b9,
  abstract     = {An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (pp'-DDE), hexachlorobenzene (HCB) and chlordanes in 58 cases with testicular cancer, 61 age-matched controls and 44 case mothers and 45 control mothers. In that report, significant increase of odds ratio (OR) was found for sum of PCBs, HCB, trans- and cis-nonachlordane in case mothers. These data have now been further analysed for 37 congeners of PCBs. No significant differences were found among cases and controls. However, case mothers had significantly increased concentrations of a number of PCB congeners. A priori decided grouping of PCBs yielded for oestrogenic PCBs OR = 2.4, 95% confidence interval (CI) = 0.95-6.0, enzyme-inducing PCBsOR = 2.6, 95% CI = 1.03-6.5 and toxic equivalents (TEQ) yielded OR = 3.3, 95% CI = 1.3-8.4. These data further elucidate the role of foetal exposure to different PCB congeners in the aetiology of testicular cancer.},
  author       = {Hardell, L and van Bavel, B and Lindstrom, G and Carlberg, M and Eriksson, Mikael and Dreifaldt, AC and Wijkstrom, H and Starkhammar, H and Hallquist, A and Kolmert, T},
  issn         = {0105-6263},
  keyword      = {polychlorinated biphenyls,aetiology,perinatal exposure,testicular,cancer},
  language     = {eng},
  number       = {5},
  pages        = {282--290},
  publisher    = {Wiley-Blackwell},
  series       = {International Journal of Andrology},
  title        = {Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer},
  url          = {http://dx.doi.org/10.1111/j.1365-2605.2004.00489.x},
  volume       = {27},
  year         = {2004},
}