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Hormone replacement therapy, calcium and vitamin D-3 versus calcium and vitamin D-3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

Forsblad d'Elia, H; Christgau, S; Mattsson, LA; Saxne, Tore LU ; Ohlsson, C; Nordborg, E and Carlsten, H (2004) In Arthritis Research and Therapy 6(5). p.457-468
Abstract
This study aimed to evaluate the effects of hormone replacement therapy (HRT), known to prevent osteoporosis and fractures, on markers of bone and cartilage metabolism. Furthermore, we assessed whether changes in these markers corresponded to alterations in bone mineral density and radiographic joint destructions in postmenopausal women with rheumatoid arthritis. Eighty-eight women were randomized to receive HRT, calcium, and vitamin D-3, or calcium and vitamin D-3 alone, for 2 years. Bone turnover was studied by analyzing serum levels of C-terminal telopeptide fragments of type I collagen (CTX-I), C-terminal telopeptide of type I collagen (ICTP), bone sialoprotein, and C-terminal propeptide of type I procollagen ( PICP) and cartilage... (More)
This study aimed to evaluate the effects of hormone replacement therapy (HRT), known to prevent osteoporosis and fractures, on markers of bone and cartilage metabolism. Furthermore, we assessed whether changes in these markers corresponded to alterations in bone mineral density and radiographic joint destructions in postmenopausal women with rheumatoid arthritis. Eighty-eight women were randomized to receive HRT, calcium, and vitamin D-3, or calcium and vitamin D-3 alone, for 2 years. Bone turnover was studied by analyzing serum levels of C-terminal telopeptide fragments of type I collagen (CTX-I), C-terminal telopeptide of type I collagen (ICTP), bone sialoprotein, and C-terminal propeptide of type I procollagen ( PICP) and cartilage turnover by urinary levels of collagen type II C-telopeptide degradation fragments (CTX-II) and cartilage oligomeric matrix protein (COMP) in serum. Treatment with HRT resulted in decrease in CTX-I (P<0.001), ICTP ( P<0.001), PICP (P<0.05), COMP (P<0.01), and CTX-II (P<0.05) at 2 years. Reductions in CTX-I, ICTP, and PICP were associated with improved bone mineral density. Of the markers tested, CTX-I reflected bone turnover most sensitively; it was reduced by 53&PLUSMN;6% in the patients receiving HRT. Baseline ICTP (P<0.001), CTX-II (P<0.01), and COMP (P<0.05) correlated with the Larsen score. We suggest that biochemical markers of bone and cartilage turnover may provide a useful tool for assessing novel treatment modalities in arthritis, concerning both joint protection and prevention of osteoporosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone turnover, hormone replacement therapy, rheumatoid arthritis, osteoporosis, cartilage turnover
in
Arthritis Research and Therapy
volume
6
issue
5
pages
457 - 468
publisher
BioMed Central
external identifiers
  • wos:000223992200013
  • scopus:20444479191
ISSN
1478-6362
DOI
10.1186/ar1215
language
English
LU publication?
yes
id
197ad70d-8e49-4937-b5f3-00d6387939b9 (old id 267601)
date added to LUP
2007-10-22 13:27:52
date last changed
2017-07-30 03:54:55
@article{197ad70d-8e49-4937-b5f3-00d6387939b9,
  abstract     = {This study aimed to evaluate the effects of hormone replacement therapy (HRT), known to prevent osteoporosis and fractures, on markers of bone and cartilage metabolism. Furthermore, we assessed whether changes in these markers corresponded to alterations in bone mineral density and radiographic joint destructions in postmenopausal women with rheumatoid arthritis. Eighty-eight women were randomized to receive HRT, calcium, and vitamin D-3, or calcium and vitamin D-3 alone, for 2 years. Bone turnover was studied by analyzing serum levels of C-terminal telopeptide fragments of type I collagen (CTX-I), C-terminal telopeptide of type I collagen (ICTP), bone sialoprotein, and C-terminal propeptide of type I procollagen ( PICP) and cartilage turnover by urinary levels of collagen type II C-telopeptide degradation fragments (CTX-II) and cartilage oligomeric matrix protein (COMP) in serum. Treatment with HRT resulted in decrease in CTX-I (P&lt;0.001), ICTP ( P&lt;0.001), PICP (P&lt;0.05), COMP (P&lt;0.01), and CTX-II (P&lt;0.05) at 2 years. Reductions in CTX-I, ICTP, and PICP were associated with improved bone mineral density. Of the markers tested, CTX-I reflected bone turnover most sensitively; it was reduced by 53&amp;PLUSMN;6% in the patients receiving HRT. Baseline ICTP (P&lt;0.001), CTX-II (P&lt;0.01), and COMP (P&lt;0.05) correlated with the Larsen score. We suggest that biochemical markers of bone and cartilage turnover may provide a useful tool for assessing novel treatment modalities in arthritis, concerning both joint protection and prevention of osteoporosis.},
  author       = {Forsblad d'Elia, H and Christgau, S and Mattsson, LA and Saxne, Tore and Ohlsson, C and Nordborg, E and Carlsten, H},
  issn         = {1478-6362},
  keyword      = {bone turnover,hormone replacement therapy,rheumatoid arthritis,osteoporosis,cartilage turnover},
  language     = {eng},
  number       = {5},
  pages        = {457--468},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Hormone replacement therapy, calcium and vitamin D-3 versus calcium and vitamin D-3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]},
  url          = {http://dx.doi.org/10.1186/ar1215},
  volume       = {6},
  year         = {2004},
}