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Depletion of mucosal substance P in acute otitis media

Caye-Thomasen, P; Schmidt, P T; Hermansson, Ann LU ; Holst, J J and Thomsen, J (2004) In Acta Oto-Laryngologica 124(7). p.794-797
Abstract
Objective-The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. Material and Methods-To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. Results-Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even... (More)
Objective-The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. Material and Methods-To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. Results-Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even further reduced on Day 3, whereas partial replenishment was found on Day 6. Conclusion-SP seems to be depleted in the rat middle ear mucosa in the hyperacute phase of AOM. This depletion is followed by replenishment and the concentration of SP approaches its normal level 6 days post-inoculation. The release of SP may be the trigger of the concurrent bone resorption and may further augment the inflammatory response to the bacterial colonization. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurogenic inflammation, bone modeling, middle ear infection, neuropeptides, radioimmunoassay
in
Acta Oto-Laryngologica
volume
124
issue
7
pages
794 - 797
publisher
Taylor & Francis
external identifiers
  • wos:000223997900006
  • scopus:4644247305
ISSN
1651-2251
DOI
10.1080/00016480410017972
language
English
LU publication?
yes
id
33060d0e-3df6-4b52-bb36-3962a7e66a36 (old id 267653)
date added to LUP
2007-10-17 16:25:17
date last changed
2017-01-01 07:00:25
@article{33060d0e-3df6-4b52-bb36-3962a7e66a36,
  abstract     = {Objective-The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. Material and Methods-To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. Results-Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even further reduced on Day 3, whereas partial replenishment was found on Day 6. Conclusion-SP seems to be depleted in the rat middle ear mucosa in the hyperacute phase of AOM. This depletion is followed by replenishment and the concentration of SP approaches its normal level 6 days post-inoculation. The release of SP may be the trigger of the concurrent bone resorption and may further augment the inflammatory response to the bacterial colonization.},
  author       = {Caye-Thomasen, P and Schmidt, P T and Hermansson, Ann and Holst, J J and Thomsen, J},
  issn         = {1651-2251},
  keyword      = {neurogenic inflammation,bone modeling,middle ear infection,neuropeptides,radioimmunoassay},
  language     = {eng},
  number       = {7},
  pages        = {794--797},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Depletion of mucosal substance P in acute otitis media},
  url          = {http://dx.doi.org/10.1080/00016480410017972},
  volume       = {124},
  year         = {2004},
}