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Antibody response to the Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in healthy and infection-prone individuals with IgG3 subclass deficiency

Hahn-Zoric, M; Ulanova, M; Friman, V; Bjorkander, J; Oxelius, Vivi-Anne LU ; Lucas, A and Hanson, LA (2004) In Journal of Clinical Immunology 24(5). p.561-570
Abstract
Searching for a possible explanation for the phenotypic heterogeneity in IgG3 deficiency, we studied the antibody response to a polysaccharide and a protein antigen in IgG3-deficient (IgG3d) adults after vaccination with Haemophilus influenzae type b capsular polysaccharide (Hib CP) conjugated to tetanus toxoid. Distribution of isotypes, idiotypes, clonotypes, and Gm allotypes were compared. All the vaccinated individuals, irrespective of the level of IgG3 and proneness to infections, developed protective levels of anti-Hib CP. Significantly lower prevaccination levels of IgG2 ( p < 0.05) and IgG4 anti-Hib CP ( p < 0.04 and p < 0.03) were noted among the infection-prone compared to the healthy IgG3d individuals and/or controls.... (More)
Searching for a possible explanation for the phenotypic heterogeneity in IgG3 deficiency, we studied the antibody response to a polysaccharide and a protein antigen in IgG3-deficient (IgG3d) adults after vaccination with Haemophilus influenzae type b capsular polysaccharide (Hib CP) conjugated to tetanus toxoid. Distribution of isotypes, idiotypes, clonotypes, and Gm allotypes were compared. All the vaccinated individuals, irrespective of the level of IgG3 and proneness to infections, developed protective levels of anti-Hib CP. Significantly lower prevaccination levels of IgG2 ( p < 0.05) and IgG4 anti-Hib CP ( p < 0.04 and p < 0.03) were noted among the infection-prone compared to the healthy IgG3d individuals and/or controls. Seventy percent of the IgG3d patients and none of the controls had the low responding Gm(ga-n/ga-n) genotype, while the majority of the controls had the alternative Gm(bfn/bfn) genotype. The conjugate ACT-HIB(R) vaccine efficiently overcomes the IgG3 subclass deficiency state and the genetic predisposition for lower responsiveness, providing protection against Hib and tetanus infections. The proneness to infection in some IgG3d individuals may relate to their low prevaccination antibody levels. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hib capsular polysaccharide, IgG3 deficiency, antibody response, tetanus toxoid
in
Journal of Clinical Immunology
volume
24
issue
5
pages
561 - 570
publisher
Springer
external identifiers
  • pmid:15359115
  • wos:000223771200010
  • scopus:4544366624
ISSN
0271-9142
DOI
10.1023/B:JOCI.0000040927.15641.0c
language
English
LU publication?
yes
id
3905dacb-7c25-489a-a2c3-c681f0a4725a (old id 267746)
date added to LUP
2007-08-02 14:43:16
date last changed
2017-01-01 07:21:17
@article{3905dacb-7c25-489a-a2c3-c681f0a4725a,
  abstract     = {Searching for a possible explanation for the phenotypic heterogeneity in IgG3 deficiency, we studied the antibody response to a polysaccharide and a protein antigen in IgG3-deficient (IgG3d) adults after vaccination with Haemophilus influenzae type b capsular polysaccharide (Hib CP) conjugated to tetanus toxoid. Distribution of isotypes, idiotypes, clonotypes, and Gm allotypes were compared. All the vaccinated individuals, irrespective of the level of IgG3 and proneness to infections, developed protective levels of anti-Hib CP. Significantly lower prevaccination levels of IgG2 ( p &lt; 0.05) and IgG4 anti-Hib CP ( p &lt; 0.04 and p &lt; 0.03) were noted among the infection-prone compared to the healthy IgG3d individuals and/or controls. Seventy percent of the IgG3d patients and none of the controls had the low responding Gm(ga-n/ga-n) genotype, while the majority of the controls had the alternative Gm(bfn/bfn) genotype. The conjugate ACT-HIB(R) vaccine efficiently overcomes the IgG3 subclass deficiency state and the genetic predisposition for lower responsiveness, providing protection against Hib and tetanus infections. The proneness to infection in some IgG3d individuals may relate to their low prevaccination antibody levels.},
  author       = {Hahn-Zoric, M and Ulanova, M and Friman, V and Bjorkander, J and Oxelius, Vivi-Anne and Lucas, A and Hanson, LA},
  issn         = {0271-9142},
  keyword      = {Hib capsular polysaccharide,IgG3 deficiency,antibody response,tetanus toxoid},
  language     = {eng},
  number       = {5},
  pages        = {561--570},
  publisher    = {Springer},
  series       = {Journal of Clinical Immunology},
  title        = {Antibody response to the Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in healthy and infection-prone individuals with IgG3 subclass deficiency},
  url          = {http://dx.doi.org/10.1023/B:JOCI.0000040927.15641.0c},
  volume       = {24},
  year         = {2004},
}