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Autoimmune hematological disorders

Provan, Drew and Semple, John W. LU (2024) p.299-319
Abstract

Autoimmune diseases are disorders where the immune system reacts against self-antigens to cause disease. Autoimmune disorders occur in about 5-7% of the population, although many individuals have no symptoms. In all, there are more than 70 different disorders, most of which are uncommon, apart from rheumatoid disease and autoimmune thyroiditis. Autoimmune diseases are clinical syndromes mediated by the activation of T or B lymphocytes, or both, in the absence of infection or other discernible cause. Animal models have aided in the identification of target genes, we have gained considerable insight into the pathogenetic basis of these complex diseases. This chapter will highlight the pathophysiological mechanism that lead to autoimmunity... (More)

Autoimmune diseases are disorders where the immune system reacts against self-antigens to cause disease. Autoimmune disorders occur in about 5-7% of the population, although many individuals have no symptoms. In all, there are more than 70 different disorders, most of which are uncommon, apart from rheumatoid disease and autoimmune thyroiditis. Autoimmune diseases are clinical syndromes mediated by the activation of T or B lymphocytes, or both, in the absence of infection or other discernible cause. Animal models have aided in the identification of target genes, we have gained considerable insight into the pathogenetic basis of these complex diseases. This chapter will highlight the pathophysiological mechanism that lead to autoimmunity and will focus on cytopenias, particularly on immune thrombocytopenia (ITP).

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Adaptive immunity, Animal models, Autoantibodies, Autoimmunity, Genetics, Immune thrombocytopenia (ITP), Innate immunity, Major histocompatibility complex (MHC), Self-tolerance, T cells, Therapy
host publication
Molecular Hematology
edition
5
pages
21 pages
publisher
Wiley
external identifiers
  • scopus:85190186146
ISBN
9781394180455
9781394180486
DOI
10.1002/9781394180486.ch21
language
English
LU publication?
yes
id
2677bce8-fafd-4aa8-950c-2442ee2643e7
date added to LUP
2025-01-13 13:55:48
date last changed
2025-07-15 04:37:38
@inbook{2677bce8-fafd-4aa8-950c-2442ee2643e7,
  abstract     = {{<p>Autoimmune diseases are disorders where the immune system reacts against self-antigens to cause disease. Autoimmune disorders occur in about 5-7% of the population, although many individuals have no symptoms. In all, there are more than 70 different disorders, most of which are uncommon, apart from rheumatoid disease and autoimmune thyroiditis. Autoimmune diseases are clinical syndromes mediated by the activation of T or B lymphocytes, or both, in the absence of infection or other discernible cause. Animal models have aided in the identification of target genes, we have gained considerable insight into the pathogenetic basis of these complex diseases. This chapter will highlight the pathophysiological mechanism that lead to autoimmunity and will focus on cytopenias, particularly on immune thrombocytopenia (ITP).</p>}},
  author       = {{Provan, Drew and Semple, John W.}},
  booktitle    = {{Molecular Hematology}},
  isbn         = {{9781394180455}},
  keywords     = {{Adaptive immunity; Animal models; Autoantibodies; Autoimmunity; Genetics; Immune thrombocytopenia (ITP); Innate immunity; Major histocompatibility complex (MHC); Self-tolerance; T cells; Therapy}},
  language     = {{eng}},
  pages        = {{299--319}},
  publisher    = {{Wiley}},
  title        = {{Autoimmune hematological disorders}},
  url          = {{http://dx.doi.org/10.1002/9781394180486.ch21}},
  doi          = {{10.1002/9781394180486.ch21}},
  year         = {{2024}},
}