Aberrant IgG2 antibody response to Neisseria Meningitidis polysaccharide A after vaccination in frequently infected compared to healthy IgA-deficient individuals
(2004) In Scandinavian Journal of Immunology 60(3). p.292-298- Abstract
- In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in... (More)
- In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls (P < 0.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection-prone than in the healthy IgAd individuals (P < 0.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection-prone IgAd patients compared to healthy IgAd individuals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/268770
- author
- Friman, V ; Hahn-Zoric, M ; Bjorkander, J ; Oxelius, Vivi-Anne LU and Hanson, LA
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Immunology
- volume
- 60
- issue
- 3
- pages
- 292 - 298
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:15320887
- wos:000223472000011
- scopus:4344598007
- ISSN
- 1365-3083
- DOI
- 10.1111/j.0300-9475.2004.01459.x
- language
- English
- LU publication?
- yes
- id
- a0a21f5c-db30-48cf-96b8-066694aa5a3e (old id 268770)
- date added to LUP
- 2016-04-01 17:01:51
- date last changed
- 2022-03-15 04:38:22
@article{a0a21f5c-db30-48cf-96b8-066694aa5a3e, abstract = {{In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls (P < 0.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection-prone than in the healthy IgAd individuals (P < 0.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection-prone IgAd patients compared to healthy IgAd individuals.}}, author = {{Friman, V and Hahn-Zoric, M and Bjorkander, J and Oxelius, Vivi-Anne and Hanson, LA}}, issn = {{1365-3083}}, language = {{eng}}, number = {{3}}, pages = {{292--298}}, publisher = {{Wiley-Blackwell}}, series = {{Scandinavian Journal of Immunology}}, title = {{Aberrant IgG2 antibody response to Neisseria Meningitidis polysaccharide A after vaccination in frequently infected compared to healthy IgA-deficient individuals}}, url = {{http://dx.doi.org/10.1111/j.0300-9475.2004.01459.x}}, doi = {{10.1111/j.0300-9475.2004.01459.x}}, volume = {{60}}, year = {{2004}}, }