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Aberrant IgG2 antibody response to Neisseria Meningitidis polysaccharide A after vaccination in frequently infected compared to healthy IgA-deficient individuals

Friman, V; Hahn-Zoric, M; Bjorkander, J; Oxelius, Vivi-Anne LU and Hanson, LA (2004) In Scandinavian Journal of Immunology 60(3). p.292-298
Abstract
In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in... (More)
In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls (P < 0.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection-prone than in the healthy IgAd individuals (P < 0.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection-prone IgAd patients compared to healthy IgAd individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Immunology
volume
60
issue
3
pages
292 - 298
publisher
Wiley-Blackwell
external identifiers
  • pmid:15320887
  • wos:000223472000011
  • scopus:4344598007
ISSN
1365-3083
DOI
10.1111/j.0300-9475.2004.01459.x
language
English
LU publication?
yes
id
a0a21f5c-db30-48cf-96b8-066694aa5a3e (old id 268770)
date added to LUP
2007-08-02 13:23:12
date last changed
2017-10-22 04:48:03
@article{a0a21f5c-db30-48cf-96b8-066694aa5a3e,
  abstract     = {In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls (P &lt; 0.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection-prone than in the healthy IgAd individuals (P &lt; 0.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection-prone IgAd patients compared to healthy IgAd individuals.},
  author       = {Friman, V and Hahn-Zoric, M and Bjorkander, J and Oxelius, Vivi-Anne and Hanson, LA},
  issn         = {1365-3083},
  language     = {eng},
  number       = {3},
  pages        = {292--298},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Immunology},
  title        = {Aberrant IgG2 antibody response to Neisseria Meningitidis polysaccharide A after vaccination in frequently infected compared to healthy IgA-deficient individuals},
  url          = {http://dx.doi.org/10.1111/j.0300-9475.2004.01459.x},
  volume       = {60},
  year         = {2004},
}