Advanced

Low birth weight in combination with catch-up growth predicts the occurrence of the metabolic syndrome in men at late middle age: the Atherosclerosis and Insulin Resistance study

Fagerberg, B; Bondjers, L and Nilsson, Peter LU (2004) In Journal of Internal Medicine1989-01-01+01:00 256(3). p.254-259
Abstract
Objectives. To study the combined effects of a low birth weight and a pronounced weight increase up to early adulthood on the presence of cardiovascular risk factors constituting the metabolic syndrome in late middle age. Design and setting. A structured sample of 396 men, 58 years old from the general population. Birth weight and weight at 18 years were obtained from medical records and registers. Main outcome measures. Body mass index (BMI), waist : hip ratio (WHR), blood pressure, serum concentrations of insulin, triglycerides, HDL cholesterol and LDL particle size at age 58 years. Results. The ratio between weight at age 18 years and birth weight correlated with a number of characteristics at age 58 years: BMI (r = 0.24, P < 0.001),... (More)
Objectives. To study the combined effects of a low birth weight and a pronounced weight increase up to early adulthood on the presence of cardiovascular risk factors constituting the metabolic syndrome in late middle age. Design and setting. A structured sample of 396 men, 58 years old from the general population. Birth weight and weight at 18 years were obtained from medical records and registers. Main outcome measures. Body mass index (BMI), waist : hip ratio (WHR), blood pressure, serum concentrations of insulin, triglycerides, HDL cholesterol and LDL particle size at age 58 years. Results. The ratio between weight at age 18 years and birth weight correlated with a number of characteristics at age 58 years: BMI (r = 0.24, P < 0.001), WHR (r = 0.24, P < 0.001), diastolic blood pressure (r = 0.13, P < 0.05), insulin (r = 0.14, P < 0.01), triglycerides (r = 0.10, P < 0.05), HDL cholesterol (r = -0.13, P < 0.01) and LDL particle size (r = -0.17, P < 0.05). The metabolic syndrome, according to current definitions, were more common at the age of 58 years in the third tertile of the weight at 18/birth ratio, than in the other tertiles (P = 0.008). Conclusions. The interaction between a low birth weight and an accelerated catch-up growth to early adulthood is associated with the occurrence of the metabolic syndrome in the late middle age. These findings are in accord with the concept that the effects of genes are conditioned by fetal growth, and that the effects of a small body size at birth are conditioned by growth during childhood and by environmental factors in childhood and adult life. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
high density lipoprotein, body size, birth weight, blood pressure, metabolic syndrome, triglycerides
in
Journal of Internal Medicine1989-01-01+01:00
volume
256
issue
3
pages
254 - 259
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:15324369
  • wos:000223470900010
  • scopus:4544310589
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2004.01361.x
language
English
LU publication?
yes
id
fc70aa6f-baa9-4bb9-8a2e-d7daa80daaa1 (old id 269243)
date added to LUP
2007-10-22 15:45:03
date last changed
2017-10-29 04:10:17
@article{fc70aa6f-baa9-4bb9-8a2e-d7daa80daaa1,
  abstract     = {Objectives. To study the combined effects of a low birth weight and a pronounced weight increase up to early adulthood on the presence of cardiovascular risk factors constituting the metabolic syndrome in late middle age. Design and setting. A structured sample of 396 men, 58 years old from the general population. Birth weight and weight at 18 years were obtained from medical records and registers. Main outcome measures. Body mass index (BMI), waist : hip ratio (WHR), blood pressure, serum concentrations of insulin, triglycerides, HDL cholesterol and LDL particle size at age 58 years. Results. The ratio between weight at age 18 years and birth weight correlated with a number of characteristics at age 58 years: BMI (r = 0.24, P &lt; 0.001), WHR (r = 0.24, P &lt; 0.001), diastolic blood pressure (r = 0.13, P &lt; 0.05), insulin (r = 0.14, P &lt; 0.01), triglycerides (r = 0.10, P &lt; 0.05), HDL cholesterol (r = -0.13, P &lt; 0.01) and LDL particle size (r = -0.17, P &lt; 0.05). The metabolic syndrome, according to current definitions, were more common at the age of 58 years in the third tertile of the weight at 18/birth ratio, than in the other tertiles (P = 0.008). Conclusions. The interaction between a low birth weight and an accelerated catch-up growth to early adulthood is associated with the occurrence of the metabolic syndrome in the late middle age. These findings are in accord with the concept that the effects of genes are conditioned by fetal growth, and that the effects of a small body size at birth are conditioned by growth during childhood and by environmental factors in childhood and adult life.},
  author       = {Fagerberg, B and Bondjers, L and Nilsson, Peter},
  issn         = {1365-2796},
  keyword      = {high density lipoprotein,body size,birth weight,blood pressure,metabolic syndrome,triglycerides},
  language     = {eng},
  number       = {3},
  pages        = {254--259},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {Low birth weight in combination with catch-up growth predicts the occurrence of the metabolic syndrome in men at late middle age: the Atherosclerosis and Insulin Resistance study},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2004.01361.x},
  volume       = {256},
  year         = {2004},
}