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Resistance to phagocytosis in Streptococcus pyogenes

Carlsson, Fredric LU (2005) In Lund University Faculty of Medicine Doctoral Dissertation Series 83,5638888888889.
Abstract
Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.
Abstract (Swedish)
Popular Abstract in Swedish

Denna avhandling beskriver studier av de mekanismer varmed bakterien Streptococcus pyogenes undviker komplementdeposition och fagocytos.
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • professor Wessels, Michael R., Harvad Medical School
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Infektioner, Infections, Medicine (human and vertebrates), Medicin (människa och djur), phagocytosis, innate immunity, complement, Streptococcus pyogenes, M protein
in
Lund University Faculty of Medicine Doctoral Dissertation Series
volume
83,5638888888889
publisher
Department of Laboratory Medicine, Lund University
defense location
Segerfalkssalen
defense date
2005-05-21 09:30:00
ISSN
1652-8220
ISBN
91-85439-38-X
language
English
LU publication?
yes
additional info
F Carlsson, K Berggård, M Stålhammar-Carlemalm and G Lindahl. 2003. Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein. J Exp Med, vol 198 pp 1057-1068.
F Carlsson, C Sandin and G Lindahl. 2005. Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway. Mol Microbiol., vol 56 pp 28-39.
id
26af57a6-2f5c-498c-a9a6-b3f047130304 (old id 547386)
date added to LUP
2016-04-01 16:14:29
date last changed
2019-05-22 05:57:57
@phdthesis{26af57a6-2f5c-498c-a9a6-b3f047130304,
  abstract     = {{Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.}},
  author       = {{Carlsson, Fredric}},
  isbn         = {{91-85439-38-X}},
  issn         = {{1652-8220}},
  keywords     = {{Infektioner; Infections; Medicine (human and vertebrates); Medicin (människa och djur); phagocytosis; innate immunity; complement; Streptococcus pyogenes; M protein}},
  language     = {{eng}},
  publisher    = {{Department of Laboratory Medicine, Lund University}},
  school       = {{Lund University}},
  series       = {{Lund University Faculty of Medicine Doctoral Dissertation Series}},
  title        = {{Resistance to phagocytosis in Streptococcus pyogenes}},
  volume       = {{83,5638888888889}},
  year         = {{2005}},
}