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Plasminogen is a critical host pathogenicity factor for group A streptococcal infection

Sun, HM; Ringdahl, Ulrika LU ; Homeister, JW; Fay, WP; Engleberg, NC; Yang, AY; Rozek, LS; Wang, XX; Sjöbring, Ulf LU and Ginsburg, D (2004) In Science 305(5688). p.1283-1286
Abstract
Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
305
issue
5688
pages
1283 - 1286
publisher
The American Association for the Advancement of Science
external identifiers
  • wos:000223624600039
  • pmid:15333838
  • scopus:4344601240
ISSN
1095-9203
DOI
10.1126/science.1101245
language
English
LU publication?
yes
id
1a18611a-23d2-4503-8471-27d99fe6967e (old id 270682)
date added to LUP
2007-11-02 10:26:37
date last changed
2017-10-01 04:54:20
@article{1a18611a-23d2-4503-8471-27d99fe6967e,
  abstract     = {Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.},
  author       = {Sun, HM and Ringdahl, Ulrika and Homeister, JW and Fay, WP and Engleberg, NC and Yang, AY and Rozek, LS and Wang, XX and Sjöbring, Ulf and Ginsburg, D},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5688},
  pages        = {1283--1286},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Plasminogen is a critical host pathogenicity factor for group A streptococcal infection},
  url          = {http://dx.doi.org/10.1126/science.1101245},
  volume       = {305},
  year         = {2004},
}