Non-reproductive effects of follicle-stimulating hormone in young men
(2023) In Andrology 11(3). p.471-477- Abstract
Objective: Follicle-stimulating hormone (FSH) receptor expression has been reported in many extra-gonadal tissues, raising the question of non-reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off-target effects of FSH is warranted. Methods: In total, 33 healthy young men (mean age 30 years) were included in the study. All received an s.c. injection of gonadotropin-releasing hormone (GnRH) antagonist and n = 16 were randomized to 300 IU recombinant FSH (300 IE 3 times/week) for 5 weeks at first visit (V1) whereas n = 17 served as controls. Blood samples were taken at (V1), after 3 weeks (V2), and after 5 weeks (V3), when the study ended. At V2, all... (More)
Objective: Follicle-stimulating hormone (FSH) receptor expression has been reported in many extra-gonadal tissues, raising the question of non-reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off-target effects of FSH is warranted. Methods: In total, 33 healthy young men (mean age 30 years) were included in the study. All received an s.c. injection of gonadotropin-releasing hormone (GnRH) antagonist and n = 16 were randomized to 300 IU recombinant FSH (300 IE 3 times/week) for 5 weeks at first visit (V1) whereas n = 17 served as controls. Blood samples were taken at (V1), after 3 weeks (V2), and after 5 weeks (V3), when the study ended. At V2, all subjects received 1000 mg testosterone undecanoate i.m. A standard set of bio- and inflammatory markers were compared between the groups using the Mann–Whitney test adjusted for multiple testing. Results: As compared to controls, the FSH treated men had higher SHBG and albumin concentrations at V2 (p = 0.024 and 0.027, respectively), and lower levels of alanine aminotransferase (p = 0.026) and magnesium (p = 0.028) at V3. However, none of the results remained statistically significant after Bonferroni correction (p > 0.0011). Conclusions: FSH had no significant effects on non-reproductive organs when given in standard therapeutic doses to young men for 5 weeks. Therefore, the FSH treatment can be considered safe in otherwise healthy young men, constituting candidates for the infertility treatment with FSH.
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- author
- Elenkov, Angel LU ; Wirestrand, Elin ; Hagsund, Agnes ; Huhtaniemi, Ilpo LU ; Giwercman, Yvonne Lundberg LU and Giwercman, Aleksander LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- FSH, inflammation, male infertility, metabolism
- in
- Andrology
- volume
- 11
- issue
- 3
- pages
- 471 - 477
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:36451611
- scopus:85146330460
- ISSN
- 2047-2919
- DOI
- 10.1111/andr.13335
- language
- English
- LU publication?
- yes
- id
- 270a5a5e-80ec-4cfd-a895-ecc099827e79
- date added to LUP
- 2023-02-16 08:29:25
- date last changed
- 2024-06-14 00:07:53
@article{270a5a5e-80ec-4cfd-a895-ecc099827e79,
abstract = {{<p>Objective: Follicle-stimulating hormone (FSH) receptor expression has been reported in many extra-gonadal tissues, raising the question of non-reproductive effects of FSH. Because of increasing usage of FSH in treatment of male infertility, deeper knowledge of possible harmful off-target effects of FSH is warranted. Methods: In total, 33 healthy young men (mean age 30 years) were included in the study. All received an s.c. injection of gonadotropin-releasing hormone (GnRH) antagonist and n = 16 were randomized to 300 IU recombinant FSH (300 IE 3 times/week) for 5 weeks at first visit (V1) whereas n = 17 served as controls. Blood samples were taken at (V1), after 3 weeks (V2), and after 5 weeks (V3), when the study ended. At V2, all subjects received 1000 mg testosterone undecanoate i.m. A standard set of bio- and inflammatory markers were compared between the groups using the Mann–Whitney test adjusted for multiple testing. Results: As compared to controls, the FSH treated men had higher SHBG and albumin concentrations at V2 (p = 0.024 and 0.027, respectively), and lower levels of alanine aminotransferase (p = 0.026) and magnesium (p = 0.028) at V3. However, none of the results remained statistically significant after Bonferroni correction (p > 0.0011). Conclusions: FSH had no significant effects on non-reproductive organs when given in standard therapeutic doses to young men for 5 weeks. Therefore, the FSH treatment can be considered safe in otherwise healthy young men, constituting candidates for the infertility treatment with FSH.</p>}},
author = {{Elenkov, Angel and Wirestrand, Elin and Hagsund, Agnes and Huhtaniemi, Ilpo and Giwercman, Yvonne Lundberg and Giwercman, Aleksander}},
issn = {{2047-2919}},
keywords = {{FSH; inflammation; male infertility; metabolism}},
language = {{eng}},
number = {{3}},
pages = {{471--477}},
publisher = {{Wiley-Blackwell}},
series = {{Andrology}},
title = {{Non-reproductive effects of follicle-stimulating hormone in young men}},
url = {{http://dx.doi.org/10.1111/andr.13335}},
doi = {{10.1111/andr.13335}},
volume = {{11}},
year = {{2023}},
}