UVB radiation represses CYLD expression in melanocytes
(2017) In Oncology Letters 14(6). p.7262-7268- Abstract
CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study... (More)
CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.
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- author
- Kuphal, Silke ; Schneider, Nadja ; Massoumi, Ramin LU ; Hellerbrand, Claus and Bosserhoff, Anja Katrin
- organization
- publishing date
- 2017-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CYLD, ERK, Melanocytes, SNAIL1, UVB
- in
- Oncology Letters
- volume
- 14
- issue
- 6
- pages
- 7 pages
- publisher
- Spandidos Publications
- external identifiers
-
- wos:000417293400128
- pmid:29344161
- scopus:85032672239
- ISSN
- 1792-1074
- DOI
- 10.3892/ol.2017.7120
- language
- English
- LU publication?
- yes
- id
- 2720afb3-21b1-4a47-a835-fab6e76a581a
- date added to LUP
- 2017-11-22 08:27:22
- date last changed
- 2025-01-08 01:03:14
@article{2720afb3-21b1-4a47-a835-fab6e76a581a,
abstract = {{<p>CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.</p>}},
author = {{Kuphal, Silke and Schneider, Nadja and Massoumi, Ramin and Hellerbrand, Claus and Bosserhoff, Anja Katrin}},
issn = {{1792-1074}},
keywords = {{CYLD; ERK; Melanocytes; SNAIL1; UVB}},
language = {{eng}},
month = {{12}},
number = {{6}},
pages = {{7262--7268}},
publisher = {{Spandidos Publications}},
series = {{Oncology Letters}},
title = {{UVB radiation represses CYLD expression in melanocytes}},
url = {{http://dx.doi.org/10.3892/ol.2017.7120}},
doi = {{10.3892/ol.2017.7120}},
volume = {{14}},
year = {{2017}},
}