Advanced

UVB radiation represses CYLD expression in melanocytes

Kuphal, Silke; Schneider, Nadja; Massoumi, Ramin LU ; Hellerbrand, Claus and Bosserhoff, Anja Katrin (2017) In Oncology Letters 14(6). p.7262-7268
Abstract

CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study... (More)

CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CYLD, ERK, Melanocytes, SNAIL1, UVB
in
Oncology Letters
volume
14
issue
6
pages
7 pages
publisher
Spandidos Publications
external identifiers
  • scopus:85032672239
  • wos:000417293400128
ISSN
1792-1074
DOI
10.3892/ol.2017.7120
language
English
LU publication?
yes
id
2720afb3-21b1-4a47-a835-fab6e76a581a
date added to LUP
2017-11-22 08:27:22
date last changed
2018-02-22 03:00:30
@article{2720afb3-21b1-4a47-a835-fab6e76a581a,
  abstract     = {<p>CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.</p>},
  author       = {Kuphal, Silke and Schneider, Nadja and Massoumi, Ramin and Hellerbrand, Claus and Bosserhoff, Anja Katrin},
  issn         = {1792-1074},
  keyword      = {CYLD,ERK,Melanocytes,SNAIL1,UVB},
  language     = {eng},
  month        = {12},
  number       = {6},
  pages        = {7262--7268},
  publisher    = {Spandidos Publications},
  series       = {Oncology Letters},
  title        = {UVB radiation represses CYLD expression in melanocytes},
  url          = {http://dx.doi.org/10.3892/ol.2017.7120},
  volume       = {14},
  year         = {2017},
}