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Visual function in young adults following intrauterine growth retardation

Martin, L; Ley, David LU ; Marsal, Karel LU and Hellstrom, A (2004) In Journal of Pediatric Ophthalmology and Strabismus 41(4). p.212-218
Abstract
Background: Intrauterine growth retardation (IUGR) resulting in infants born small for gestational age is a known risk factor for neurologic deficits and may predispose to poor cognitive development later in life. We recently found an association between IUGR and a reduced neuroretinal rim area at 18 years of age. We evaluated the possible association between IUGR and visual function. Subjects and Methods: We studied 26 subjects who had been born small for gestational age and 20 subjects whose birth weights were appropriate for gestational age (controls) using letter acuity thresholds, color vision testing, full-threshold frequency doubling technology perimetry, and rarebit perimetry at 18 years of age. Results: Eight of the subjects who... (More)
Background: Intrauterine growth retardation (IUGR) resulting in infants born small for gestational age is a known risk factor for neurologic deficits and may predispose to poor cognitive development later in life. We recently found an association between IUGR and a reduced neuroretinal rim area at 18 years of age. We evaluated the possible association between IUGR and visual function. Subjects and Methods: We studied 26 subjects who had been born small for gestational age and 20 subjects whose birth weights were appropriate for gestational age (controls) using letter acuity thresholds, color vision testing, full-threshold frequency doubling technology perimetry, and rarebit perimetry at 18 years of age. Results: Eight of the subjects who were small for gestational age had a rarebit hit rate below the normal range as compared with none of the controls (P =.006). These 8 subjects had a significantly smaller rim-disc ratio compared with the subjects who were small for gestational age who had a normal rarebit hit rate (P =.047). The frequency doubling technology indices did not differ significantly between the control group and the group that was small for gestational age, nor did the visual acuity, refraction, and color vision test results. Conclusion: These data indicate that IUGR is associated with an increased rate of impaired visual function, which can be detected by using rarebit perimetry but not frequency doubling technology perimetry, visual acuity, or color vision tests. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Pediatric Ophthalmology and Strabismus
volume
41
issue
4
pages
212 - 218
publisher
Slack Inc
external identifiers
  • wos:000222760400007
  • scopus:3343012481
ISSN
0191-3913
language
English
LU publication?
yes
id
490b32d1-bad2-40fb-b24c-f868d9b481a4 (old id 272406)
alternative location
http://www.journalofpediatricophthalmology.com/showAbst.asp?thing=8544
date added to LUP
2007-10-25 13:43:15
date last changed
2017-10-01 03:47:16
@article{490b32d1-bad2-40fb-b24c-f868d9b481a4,
  abstract     = {Background: Intrauterine growth retardation (IUGR) resulting in infants born small for gestational age is a known risk factor for neurologic deficits and may predispose to poor cognitive development later in life. We recently found an association between IUGR and a reduced neuroretinal rim area at 18 years of age. We evaluated the possible association between IUGR and visual function. Subjects and Methods: We studied 26 subjects who had been born small for gestational age and 20 subjects whose birth weights were appropriate for gestational age (controls) using letter acuity thresholds, color vision testing, full-threshold frequency doubling technology perimetry, and rarebit perimetry at 18 years of age. Results: Eight of the subjects who were small for gestational age had a rarebit hit rate below the normal range as compared with none of the controls (P =.006). These 8 subjects had a significantly smaller rim-disc ratio compared with the subjects who were small for gestational age who had a normal rarebit hit rate (P =.047). The frequency doubling technology indices did not differ significantly between the control group and the group that was small for gestational age, nor did the visual acuity, refraction, and color vision test results. Conclusion: These data indicate that IUGR is associated with an increased rate of impaired visual function, which can be detected by using rarebit perimetry but not frequency doubling technology perimetry, visual acuity, or color vision tests.},
  author       = {Martin, L and Ley, David and Marsal, Karel and Hellstrom, A},
  issn         = {0191-3913},
  language     = {eng},
  number       = {4},
  pages        = {212--218},
  publisher    = {Slack Inc},
  series       = {Journal of Pediatric Ophthalmology and Strabismus},
  title        = {Visual function in young adults following intrauterine growth retardation},
  volume       = {41},
  year         = {2004},
}