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Association between laminin-8 and glial tumor grade, recurrence, and patient survival

Ljubimova, JY; Fugita, M; Khazenzon, NM; Das, A; Pikul, BB; Newman, D; Sekiguchi, K; Sorokin, Lydia LU ; Sasaki, T and Black, KL (2004) In Cancer 101(3). p.604-612
Abstract
BACKGROUND. The authors previously sought to identify novel markers of glioma invasion and recurrence. Their research demonstrated that brain gliomas overexpressed a subset of vascular basement components, laminins, that contained the alpha4 chain. One of these laminins, laminin-8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines. METHODS. in the current study, the authors studied glial tumors of different grades in an attempt to correlate laminin-8 expression with tumor recurrence and patient survival. Immunohistochemistry and Western blot... (More)
BACKGROUND. The authors previously sought to identify novel markers of glioma invasion and recurrence. Their research demonstrated that brain gliomas overexpressed a subset of vascular basement components, laminins, that contained the alpha4 chain. One of these laminins, laminin-8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines. METHODS. in the current study, the authors studied glial tumors of different grades in an attempt to correlate laminin-8 expression with tumor recurrence and patient survival. Immunohistochemistry and Western blot analysis were used to detect laminin isoforms of interest. RESULTS. Using immunohistochemistry and Western blot analysis, the authors confirmed high levels of laminin-8 expression in approximately 75% of the GBM cases examined and in their adjacent tissues, whereas astrocytomas of lower grades expressed for the most part a different isoform, laminin-9, which also was found in low amounts in normal brain tissue and benign meningiomas. Overexpression of laminin-8 in GBM was found to be associated with a statistically significant shorter time to tumor recurrence (P < 0.0002) and a decreased patient survival time (P < 0.015). CONCLUSIONS. The data suggest that laminin-8, which may facilitate tumor invasion, contributes to tumor regrowth after therapy. Laminin-8 may be used as a predictor of tumor recurrence and patient survival and as a potential molecular target for glioma therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glioblastoma multiforme (GBM), human glioma, vessel, blood, extracellular matrix, basement membrane, laminin-8, laminin-9, survival, invasion, recurrence
in
Cancer
volume
101
issue
3
pages
604 - 612
publisher
John Wiley & Sons
external identifiers
  • pmid:15274074
  • wos:000222770100019
  • scopus:3242777006
ISSN
1097-0142
DOI
10.1002/cncr.20397
language
English
LU publication?
yes
id
d4383925-5fc4-4feb-9dd9-38f1e860fff6 (old id 272560)
date added to LUP
2007-08-03 12:17:31
date last changed
2017-07-30 03:45:55
@article{d4383925-5fc4-4feb-9dd9-38f1e860fff6,
  abstract     = {BACKGROUND. The authors previously sought to identify novel markers of glioma invasion and recurrence. Their research demonstrated that brain gliomas overexpressed a subset of vascular basement components, laminins, that contained the alpha4 chain. One of these laminins, laminin-8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines. METHODS. in the current study, the authors studied glial tumors of different grades in an attempt to correlate laminin-8 expression with tumor recurrence and patient survival. Immunohistochemistry and Western blot analysis were used to detect laminin isoforms of interest. RESULTS. Using immunohistochemistry and Western blot analysis, the authors confirmed high levels of laminin-8 expression in approximately 75% of the GBM cases examined and in their adjacent tissues, whereas astrocytomas of lower grades expressed for the most part a different isoform, laminin-9, which also was found in low amounts in normal brain tissue and benign meningiomas. Overexpression of laminin-8 in GBM was found to be associated with a statistically significant shorter time to tumor recurrence (P &lt; 0.0002) and a decreased patient survival time (P &lt; 0.015). CONCLUSIONS. The data suggest that laminin-8, which may facilitate tumor invasion, contributes to tumor regrowth after therapy. Laminin-8 may be used as a predictor of tumor recurrence and patient survival and as a potential molecular target for glioma therapy.},
  author       = {Ljubimova, JY and Fugita, M and Khazenzon, NM and Das, A and Pikul, BB and Newman, D and Sekiguchi, K and Sorokin, Lydia and Sasaki, T and Black, KL},
  issn         = {1097-0142},
  keyword      = {glioblastoma multiforme (GBM),human glioma,vessel,blood,extracellular matrix,basement membrane,laminin-8,laminin-9,survival,invasion,recurrence},
  language     = {eng},
  number       = {3},
  pages        = {604--612},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Association between laminin-8 and glial tumor grade, recurrence, and patient survival},
  url          = {http://dx.doi.org/10.1002/cncr.20397},
  volume       = {101},
  year         = {2004},
}