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The PROTECCT-M study : a cohort study investigating associations between novel specific biomarkers, patient-related, healthcare system markers and the trajectory of COPD patients treated in primary care

Søndergaard, Jens and Halling, Anders LU (2014) In BMC Pulmonary Medicine 14.
Abstract

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is the most common severe chronic disease in primary care. It is typically diagnosed at a late stage, and it is also difficult to predict its trajectory and hence to tailor treatment and rehabilitation. The overall aim is to study determinants of exacerbations of COPD treated in primary care and to study, if the prognosis is related to patient-related, healthcare system markers or levels of the potential biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D). Furthermore, we aim to establish a cohort of COPD patients treated in Danish primary care comprising register data, data captured from the GPs' electronic patient record system (EPR)... (More)

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is the most common severe chronic disease in primary care. It is typically diagnosed at a late stage, and it is also difficult to predict its trajectory and hence to tailor treatment and rehabilitation. The overall aim is to study determinants of exacerbations of COPD treated in primary care and to study, if the prognosis is related to patient-related, healthcare system markers or levels of the potential biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D). Furthermore, we aim to establish a cohort of COPD patients treated in Danish primary care comprising register data, data captured from the GPs' electronic patient record system (EPR) and a biobank in order to make analyses on factors associated with different tractories of COPD treated in primary care.

METHODS/DESIGN: A cohort study of incident and prevalent COPD patients treated and followed by their GPs using data capture, which is a computer system collecting data from the GPs' own EPR and transferring them to the Danish General Practice Research Database. The participating COPD patients were investigated at a baseline consultation by their own GP, and the results were registered using a pop-up menu by the GP. During the consultation blood samples were taken and the patients were given a questionnaire. The patients will then be followed prospectively at yearly consultations and in between these consultations by means of the data capture system. The collected data will also be combined with register data from other sources. The data collection started in December 2012, and so far 30 practices with 77 GPs have included about 350 patients. The study aims to include 2000 patients till the end of 2016, and after that to continue to collect data on these patients using the data capture system.

DISCUSSION: The GP currently lacks tools to predict trajectory of their COPD patients. The measurement of lung function only reflects loss of lung capacity and not disease activity. Use of biomarkers for detection of early COPD could be a possible way of predicting trajectory to aid both the GP and his/her patients. This study aims to provide evidence of determinants of a COPD trajectory, including novel specific biomarkers and other patient- and healthcare system-related markers.

TRIAL REGISTRATION: ClinicalTrials.gov Protocol Registration System, Identifier: NCT01698151.

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keywords
Adult, Biomarkers/blood, Carrier Proteins/blood, Cohort Studies, Denmark, Disease Progression, Early Diagnosis, Electronic Health Records, Extracellular Matrix Proteins/blood, Female, Glycoproteins/blood, Humans, Male, Middle Aged, Practice Patterns, Physicians', Primary Health Care/methods, Prognosis, Pulmonary Disease, Chronic Obstructive/blood, Pulmonary Surfactant-Associated Protein D/blood, Registries, Research Design, Treatment Outcome
in
BMC Pulmonary Medicine
volume
14
article number
88
publisher
BioMed Central (BMC)
external identifiers
  • scopus:84902072757
  • pmid:24886233
ISSN
1471-2466
DOI
10.1186/1471-2466-14-88
language
English
LU publication?
no
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27261f5c-19db-4799-b433-7eb79716286c
date added to LUP
2019-05-27 10:36:15
date last changed
2020-01-13 01:54:34
@article{27261f5c-19db-4799-b433-7eb79716286c,
  abstract     = {<p>BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is the most common severe chronic disease in primary care. It is typically diagnosed at a late stage, and it is also difficult to predict its trajectory and hence to tailor treatment and rehabilitation. The overall aim is to study determinants of exacerbations of COPD treated in primary care and to study, if the prognosis is related to patient-related, healthcare system markers or levels of the potential biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D). Furthermore, we aim to establish a cohort of COPD patients treated in Danish primary care comprising register data, data captured from the GPs' electronic patient record system (EPR) and a biobank in order to make analyses on factors associated with different tractories of COPD treated in primary care.</p><p>METHODS/DESIGN: A cohort study of incident and prevalent COPD patients treated and followed by their GPs using data capture, which is a computer system collecting data from the GPs' own EPR and transferring them to the Danish General Practice Research Database. The participating COPD patients were investigated at a baseline consultation by their own GP, and the results were registered using a pop-up menu by the GP. During the consultation blood samples were taken and the patients were given a questionnaire. The patients will then be followed prospectively at yearly consultations and in between these consultations by means of the data capture system. The collected data will also be combined with register data from other sources. The data collection started in December 2012, and so far 30 practices with 77 GPs have included about 350 patients. The study aims to include 2000 patients till the end of 2016, and after that to continue to collect data on these patients using the data capture system.</p><p>DISCUSSION: The GP currently lacks tools to predict trajectory of their COPD patients. The measurement of lung function only reflects loss of lung capacity and not disease activity. Use of biomarkers for detection of early COPD could be a possible way of predicting trajectory to aid both the GP and his/her patients. This study aims to provide evidence of determinants of a COPD trajectory, including novel specific biomarkers and other patient- and healthcare system-related markers.</p><p>TRIAL REGISTRATION: ClinicalTrials.gov Protocol Registration System, Identifier: NCT01698151.</p>},
  author       = {Søndergaard, Jens and Halling, Anders},
  issn         = {1471-2466},
  language     = {eng},
  month        = {05},
  publisher    = {BioMed Central (BMC)},
  series       = {BMC Pulmonary Medicine},
  title        = {The PROTECCT-M study : a cohort study investigating associations between novel specific biomarkers, patient-related, healthcare system markers and the trajectory of COPD patients treated in primary care},
  url          = {http://dx.doi.org/10.1186/1471-2466-14-88},
  doi          = {10.1186/1471-2466-14-88},
  volume       = {14},
  year         = {2014},
}